A cell-permeable β-carboline compound that displays anti-inflammatory properties. Acts as a potent, ATP-competitive, and reversible inhibitor of IKK (IC₅₀ = 88 nM) with selectivity over 14 other commonly studied kinases (IC₅₀ >100 μM), including NF-κB inducing kinase. Blocks cellular IκBα phosphorylation and NF-κB activation (EC₅₀ = 5 μM in TNF-α-treated HeLa cells) in vitro and reduces TNF-α release in plasma of LPS-challenged mice in vivo (50 mg/ml, p.o.).

The IKK Inhibitor X controls the biological activity of IKK. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Target IC₅₀:88 nM against IKK

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.