401491
IKK Inhibitor XII
The IKK Inhibitor XII, also referenced under CAS 928655-63-4, controls the biological activity of IKK. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
别名:
IKK Inhibitor XII
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 10 mg/mL
运输
ambient
储存温度
2-8°C
一般描述
A cell-permeable amino-diarylbenzamide compound that acts as a potent ATP site-targeting inhibitor against IKK-1 and IKK-2 (pIC50 = 6.4 and 7.0, respectively), while exhibiting more than 50-fold less potency toward a panel of greater than 50 other kinases, including IKK-3 (pIC50<4.8), ALK5, Cdk-2, EGFR, ErbB2, GSK-3β, Plk1, Src, and VEGFR-2. Shown to effectively suppress LPS-stimulated secretion of TNF-α, IL-1β, and IL-6 from human PBMCs (pIC50 = 6.1, 6.4, and 5.7, respectively) as well as TNF-α-induced NF-κB nuclear translocation in human lung fibroblast cells (pIC50 = 5.7).
包装
Packaged under inert gas
其他说明
Christopher, J.A., et al. 2007. Bioorg. Med. Chem. Lett.17, 3972.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
So Eun Youn et al.
International journal of molecular sciences, 23(19) (2022-10-15)
PAUF, a tumor-promoting protein secreted by cancer cells, exerts paracrine effects on immune cells through TLR4 receptors expressed on immune cell surfaces. This study aimed to investigate if PAUF elicits autocrine effects on pancreatic cancer (PC) cells through TLR4, a
A frequent SNP in TRIM5I? strongly enhances the innate immune response against LINE-1 elements.
Lagisquet, et al.
Frontiers in Immunology, 14, 1168589-1168589 (2023)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持