402086
Indirubin-3ʹ-monoxime, 5-Iodo- - CAS 331467-03-9 - Calbiochem
别名:
Indirubin-3ʹ-monoxime, 5-Iodo- - CAS 331467-03-9 - Calbiochem
方案
≥97% (HPLC)
质量水平
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
dark red
溶解性
DMSO: 100 mg/mL
运输
ambient
储存温度
−20°C
一般描述
This product has been discontinued.
A highly potent cell-permeable and reversible inhibitor of glycogen synthase kinase-3β (GSK-3β; IC50 = 9 nM). Also inhibits Cdk1 (IC50 = 25 nM) and Cdk5 (IC50 = 20 nM) activities. Acts by binding to the ATP-binding pocket of these enzymes.
A highly potent, cell-permeable, and reversible inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC50 = 9 nM). Reported to inhibit GSK-3β phosphorylation of human tau protein in vitro (IC50 ~100 nM) and in cells (effective concentration = 20 µM). Also inhibits CDK1 (IC50 = 25 nM) and CDK5 (IC50 = 20 nM). Shown to inhibit phosphorylation of DARPP-32 by CDK5 in brain sections enriched for DARPP-32. Inhibition is competitive with respect to ATP.
生化/生理作用
Cell permeable: yes
Primary Target
Gsk-3β
Gsk-3β
Product competes with ATP.
Reversible: yes
Target IC50: 9 nM against GSK-3β
包装
Packaged under inert gas
制备说明
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Leclerc, S., et al. 2001. J. Biol. Chem.276, 251.
Hoessel, R., et al. 1999. Nat. Cell Biol.1, 60.
Hoessel, R., et al. 1999. Nat. Cell Biol.1, 60.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
10-13 - German Storage Class 10 to 13
法规信息
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