402086
Indirubin-3ʹ-monoxime, 5-Iodo- - CAS 331467-03-9 - Calbiochem
别名:
Indirubin-3ʹ-monoxime, 5-Iodo- - CAS 331467-03-9 - Calbiochem
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
dark red
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
This product has been discontinued.
A highly potent cell-permeable and reversible inhibitor of glycogen synthase kinase-3β (GSK-3β; IC50 = 9 nM). Also inhibits Cdk1 (IC50 = 25 nM) and Cdk5 (IC50 = 20 nM) activities. Acts by binding to the ATP-binding pocket of these enzymes.
A highly potent, cell-permeable, and reversible inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC50 = 9 nM). Reported to inhibit GSK-3β phosphorylation of human tau protein in vitro (IC50 ~100 nM) and in cells (effective concentration = 20 µM). Also inhibits CDK1 (IC50 = 25 nM) and CDK5 (IC50 = 20 nM). Shown to inhibit phosphorylation of DARPP-32 by CDK5 in brain sections enriched for DARPP-32. Inhibition is competitive with respect to ATP.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Gsk-3β
Gsk-3β
Product competes with ATP.
Reversible: yes
Target IC50: 9 nM against GSK-3β
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Leclerc, S., et al. 2001. J. Biol. Chem.276, 251.
Hoessel, R., et al. 1999. Nat. Cell Biol.1, 60.
Hoessel, R., et al. 1999. Nat. Cell Biol.1, 60.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
10-13 - German Storage Class 10 to 13
法规信息
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