A cell-permeable 6-BIO (Cat. Nos. 361550 and 361552) structural isomer that acts as an ATP-competitive inhibitor of Flt3 (IC₅₀ = 340 nM) and a caspase-independent, non-apoptotic cell death inducer (IC₅₀ of cell survival ranges from 6.0 μM to 22.0 μM). Inhibition study against 75 other kinases reveals 10- to 80-fold selectivities over a group of 14 kinases, including TSF1, Aurora-A, and Aurora-B (IC₅₀ = 3.3, 4.7, and 6.6 μM, respectively), up to 280-fold selectivities over a second group of 15 kinases, and little activity against the remaining 46 kinases of the panel (IC₅₀ >100 μM).

A cell-permeable 6-BIO structural isomer that acts as an ATP-competitive inhibitor of Flt3 and a caspase-independent, non-apoptotic cell death inducer.

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.