D-myo-Inositol 1,3,5-Trisphosphate Hexakisacetoxymethyl Ester, 2,4,6-Tri-O-butyryl-, - Calbiochem

A cell-permeable derivative of D-myo-inositol 1,3,5-trisphosphate [Ins(1,3,5)P₃].

Note: Each set contains 1 µmol Bt₃(1,3,5)IP₃/AM and 10 mg PLURONIC^® F-127 detergent (Cat. No. 540025) to aid in the solubilization of this product.

Novel analogs capable of exhibiting Ins(1,4,5)P3-like agonist or antagonist effects on calcium release are more resistant to hydrolysis and metabolic degradation than IP3 or IP4. Consequently, they can produce a prolonged activation of cellular processes dependent on the Ins(1,4,5)P3 receptor interaction. These tools are important in the elucidation of the molecular interactions of Ins(1,4,5)P3 with its intracellular receptor and with Ins(1,4,5)P3-kinase and 5-phosphatase. Acetoxymethyl esters of inositol phosphate are highly lipophilic. Hence, they easily diffuse through the cell membrane. Note: Each set contains 1 µmol of Bt₃(1,3,5)IP₃/AM and 10 mg of PLURONIC^® F-127 detergent (Cat. No. 540025) to aid in the solubilization of this product.

Cell permeable: yes

Primary Target
A cell-permeable derivative of D-myo-inositol 1,3,5-trisphosphate [Ins(1,3,5)P3]

Product does not compete with ATP.

Reversible: no

Packaged under inert gas

1 µmol Bt₃(1,3,5)IP₃/AM and 10 mg PLURONIC^® F-127 detergent.

Following reconstitution of IPx, aliquot and freeze (-20°C). Stock solutions of IPx are stable for up to 3 months. Following reconstitution of PLURONIC^® F-127 detergent, refrigerate (4°C). DO NOT FREEZE!

Rudolf, M.T., et al. 2003. Bioorg. Med. Chem.11, 3315.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pluronic is a registered trademark of BASF

Toxicity: Standard Handling (A)