412400
IQ-1
A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation.
别名:
IQ-1, 2-(4-Acetylphenylazo)-2-(3,3-dimethyl-3,4-dihydro-2H-isoquinolin-1-ylidene)-acetamide, Wnt Pathway Activator III
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关于此项目
经验公式（希尔记法）:
C21H22N4O2
化学文摘社编号:
分子量:
362.42
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
InChI key
ZXSRRUROLCGTBS-UHFFFAOYSA-N
SMILES string
N1C(Cc2c(cccc2)C1=C(N=Nc3ccc(cc3)C(=O)C)C(=O)N)(C)C
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
orange
solubility
DMSO: 50 mg/mL
shipped in
ambient
Quality Level
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General description
A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation, resulting in diminished β-catenin/p300 interaction and a concomitant increase in β-catenin/CBP usage. Co-adminitration of IQ-1 (4 µg/ml) and Wnt3a (100 ng/ml), but neither reagent alone, has been shown to be sufficient in maintaining long-term (>48 days) murine ESCs (Embryonic Stem Cells) pluripotency in the absence of serum.
Packaging
Packaged under inert gas
Other Notes
Miyabayashi, T., et al. 2007. Proc. Natl. Acad. Sci. USA104, 5668.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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