419800
PARP Inhibitor IV, IQD
The PARP Inhibitor IV, IQD, also referenced under CAS 1188540, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
别名:
PARP Inhibitor IV, IQD, 1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinoline, 1,5-Isoquinolinediol
InChI
1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)
InChI key
LFUJIPVWTMGYDG-UHFFFAOYSA-N
assay
≥98% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white to off-white
solubility
DMSO: 30 mg/mL, 0.1 M NaOH: 5 mg/mL, methanol: 8 mg/mL
shipped in
ambient
Quality Level
General description
A potent inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 390 nM). Reported to partially block SNAP (CN 487910)- induced cell death in SH-SYSY human neuroblastoma cells.
A potent, cell-permeable inhibitor of poly(ADP-ribose) polymerase (PARS; IC50 = 390 nM). Blocks nitric oxide-induced neuronal toxicity.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Poly(ADP-ribose) polymerase (PARS)
Poly(ADP-ribose) polymerase (PARS)
Product does not compete with ATP.
Reversible: no
Target IC50: 390 nM against poly(ADP-ribose) polymerase (PARS)
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
Other Notes
Kamoshima, W., et al. 1997. Neurochem. Int. 30, 305.
Dalamu, M., et al. 1996. Exp. Cell Res. 228, 14.
Zhang, J., et al. 1994. Science 263, 687.
Banasik, M., et al. 1992. J. Biol. Chem. 267, 1569.
Dalamu, M., et al. 1996. Exp. Cell Res. 228, 14.
Zhang, J., et al. 1994. Science 263, 687.
Banasik, M., et al. 1992. J. Biol. Chem. 267, 1569.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
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