419800
PARP Inhibitor IV, IQD
The PARP Inhibitor IV, IQD, also referenced under CAS 1188540, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
别名:
PARP Inhibitor IV, IQD, 1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinoline, 1,5-Isoquinolinediol
质量水平
方案
≥98% (NMR)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white to off-white
溶解性
DMSO: 30 mg/mL
0.1 M NaOH: 5 mg/mL
methanol: 8 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)
InChI key
LFUJIPVWTMGYDG-UHFFFAOYSA-N
一般描述
A potent inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 390 nM). Reported to partially block SNAP (CN 487910)- induced cell death in SH-SYSY human neuroblastoma cells.
A potent, cell-permeable inhibitor of poly(ADP-ribose) polymerase (PARS; IC50 = 390 nM). Blocks nitric oxide-induced neuronal toxicity.
生化/生理作用
Cell permeable: yes
Primary Target
Poly(ADP-ribose) polymerase (PARS)
Poly(ADP-ribose) polymerase (PARS)
Product does not compete with ATP.
Reversible: no
Target IC50: 390 nM against poly(ADP-ribose) polymerase (PARS)
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
其他说明
Kamoshima, W., et al. 1997. Neurochem. Int. 30, 305.
Dalamu, M., et al. 1996. Exp. Cell Res. 228, 14.
Zhang, J., et al. 1994. Science 263, 687.
Banasik, M., et al. 1992. J. Biol. Chem. 267, 1569.
Dalamu, M., et al. 1996. Exp. Cell Res. 228, 14.
Zhang, J., et al. 1994. Science 263, 687.
Banasik, M., et al. 1992. J. Biol. Chem. 267, 1569.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
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