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419800

PARP Inhibitor IV, IQD

Name: PARP Inhibitor IV, IQD
Brand: MM

The PARP Inhibitor IV, IQD, also referenced under CAS 1188540, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

别名:

PARP Inhibitor IV, IQD, 1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinoline, 1,5-Isoquinolinediol

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关于此项目

经验公式（希尔记法）:

C₉H₇NO₂

化学文摘社编号:

5154-02-9

分子量:

161.16

UNSPSC Code:

12352200

MDL number:

MFCD00006900

Assay:

≥98% (NMR)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

Quality Level

100

assay

≥98% (NMR)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white to off-white

solubility

DMSO: 30 mg/mL, 0.1 M NaOH: 5 mg/mL, methanol: 8 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)

InChI key

LFUJIPVWTMGYDG-UHFFFAOYSA-N

说明

General description

A potent inhibitor of poly(ADP-ribose) polymerase (PARP; IC₅₀ = 390 nM). Reported to partially block SNAP (CN 487910)- induced cell death in SH-SYSY human neuroblastoma cells.

A potent, cell-permeable inhibitor of poly(ADP-ribose) polymerase (PARS; IC₅₀ = 390 nM). Blocks nitric oxide-induced neuronal toxicity.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Poly(ADP-ribose) polymerase (PARS)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 390 nM against poly(ADP-ribose) polymerase (PARS)

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.

Other Notes

Kamoshima, W., et al. 1997. Neurochem. Int. 30, 305.
Dalamu, M., et al. 1996. Exp. Cell Res. 228, 14.
Zhang, J., et al. 1994. Science 263, 687.
Banasik, M., et al. 1992. J. Biol. Chem. 267, 1569.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

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全球贸易项目编号

货号	GTIN
419800-5MG	04055977187823