420122
JAK3 Inhibitor V
The JAK3 Inhibitor V, also referenced under CAS 932258, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
JAK3 Inhibitor V, (2-Naphthylvinyl Ketone), ZM 449829
质量水平
方案
≥98% (HPLC)
表单
waxy solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated
protect from light
颜色
white
溶解性
DMSO: 10 mg/mL
ethanol: 10 mg/mL
运输
wet ice
储存温度
−20°C
InChI
1S/C13H10O/c1-2-13(14)12-8-7-10-5-3-4-6-11(10)9-12/h2-9H,1H2
InChI key
FOTCGZPFSUWZBN-UHFFFAOYSA-N
一般描述
A breakdown product of JAK3 Inhibitor IV (Cat. No. 420121) with similar inhibitory potency (pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1). Also inhibits STAT-5 phosphorylation and T-cell proliferation.
A breakdown product of JAK3 Inhibitor-IV (Cat. No. 420121) with similar inhibitory potency (pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1). Also inhibits STAT-5 phosphorylation and T-cell proliferation.
生化/生理作用
Cell permeable: no
Product does not compete with ATP.
Reversible: no
pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in DMSO; reconstitute just prior to use.
其他说明
Brown, G.R., et al. 2000. Bioorg. Med. Chem. Lett.10, 575.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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