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Merck
CN

420122

JAK3 Inhibitor V

The JAK3 Inhibitor V, also referenced under CAS 932258, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

别名:

JAK3 Inhibitor V, (2-Naphthylvinyl Ketone), ZM 449829

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关于此项目

经验公式（希尔记法）:
C13H10O
化学文摘社编号:
4452-06-6
分子量:
182.22
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
waxy solid
Quality level:
100
Storage condition:
OK to freeze, desiccated, protect from light

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InChI key

FOTCGZPFSUWZBN-UHFFFAOYSA-N

InChI

1S/C13H10O/c1-2-13(14)12-8-7-10-5-3-4-6-11(10)9-12/h2-9H,1H2

assay

≥98% (HPLC)

form

waxy solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated, protect from light

color

white

solubility

DMSO: 10 mg/mL, ethanol: 10 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

General description

A breakdown product of JAK3 Inhibitor IV (Cat. No. 420121) with similar inhibitory potency (pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1). Also inhibits STAT-5 phosphorylation and T-cell proliferation.
A breakdown product of JAK3 Inhibitor-IV (Cat. No. 420121) with similar inhibitory potency (pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1). Also inhibits STAT-5 phosphorylation and T-cell proliferation.

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no
pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in DMSO; reconstitute just prior to use.

Other Notes

Brown, G.R., et al. 2000. Bioorg. Med. Chem. Lett.10, 575.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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相关内容

JAK/STAT Signaling Research Focus

The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway plays an important role in cell proliferation, cell differentiation, cell migration, and cell death. It is the principal signaling mechanism for a variety of cytokines and growth factors. Constitutive activation or dysregulation of JAK/STAT signaling can result in inflammatory disease, erythrocytosis, gigantism, and leukemia.

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