420210
Jervine
A cell-permeable steroidal alkaloid similar to cyclopamine that displays teratogenic effects and induces cyclopia by blocking Sonic Hedgehog signaling.
别名:
Jervine, (3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one, 11-Ketocyclopamine, Shh Signaling Antagonist III
InChI
1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3
InChI key
CLEXYFLHGFJONT-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
ethanol: 10 mg/mL, DMSO: 5 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
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General description
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Induces cyclopia by blocking shh (Sonic Hedgehog) signaling
Induces cyclopia by blocking shh (Sonic Hedgehog) signaling
Product does not compete with ATP.
Reversible: no
Target IC50: ~ 500-700 nM blocking shh (Sonic Hedgehog) signaling in s12 cells
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution in fresh DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Slight warming may be required to achieve complete solubilization in ethanol.
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Williams, J.A., et al. 2003. Proc. Natl. Acad. Sci. USA100, 4616.
Cooper, M. K., et al. 2003. Nat. Genet.33, 508.
Mistretta, C.M., 2003. Dev. Biol.254, 1.
ten Berge, D., et al. 2001. Development128, 2929.
Cooper, M.K., et al. 1998. Science280, 1603.
Cooper, M. K., et al. 2003. Nat. Genet.33, 508.
Mistretta, C.M., 2003. Dev. Biol.254, 1.
ten Berge, D., et al. 2001. Development128, 2929.
Cooper, M.K., et al. 1998. Science280, 1603.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic (F)
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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