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Merck
CN

422712

Sigma-Aldrich

KN-93

InSolution, ≥95%, A cell-permeable, competitive inhibitor of Ca2+/calmodulin-dependent protein kinase II

别名:

InSolution KN-93

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关于此项目

经验公式（希尔记法）:
C26H29ClN2O4S
CAS Number:
139298-40-1
分子量:
501.04
MDL编号:
MFCD03788201
UNSPSC代码:
12352200
NACRES:
NA.77

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质量水平

100

方案

≥95% (HPLC)

表单

liquid

效能

370 nM Ki

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)
protect from light

运输

wet ice

储存温度

−20°C

SMILES字符串

[S](=O)(=O)(N(CCO)c2c(cccc2)CN(C\C=C\c3ccc(cc3)Cl)C)c1ccc(cc1)OC

InChI

1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+

InChI key

LLLQTDSSHZREGW-AATRIKPKSA-N

一般描述

A cell-permeable, competitive inhibitor of Ca2+/calmodulin-dependent protein kinase II (Ki = 370 nM). Selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.

生化/生理作用

Cell permeable: yes
Primary Target
cam kinase 2
Product does not compete with ATP.
Reversible: yes

包装

Packaged under inert gas

外形

A 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422708) in DMSO.

制备说明

Following initial thaw aliquot and freeze (-20°C).

其他说明

Fan, G.H., et al. 1999. Mol. Pharmacol.56, 39.
Tombes, R.M., et al. 1995. Cell Growth Differentiation6, 1063.
Chen, C., et al. 1994. Science266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun.195, 608.
Niki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Irritant (B)

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

闪点(°C)

87 °C - closed cup - (Dimethylsulfoxide)

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