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Merck
CN

428020

Latrunculin B

from Latrunculia magnifica, ≥95% (HPLC), solid, actin polymerization inhibitor, Calbiochem®

别名:

红海海绵素B，Latrunculia magnifica

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关于此项目

经验公式（希尔记法）:
C20H29NO5S
化学文摘社编号:
76343-94-7
分子量:
395.51
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00270879

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产品名称

红海海绵素B，Latrunculia magnifica, Latrunculin B, CAS 76343-94-7, is a unique marine toxin that inhibits actin polymerization and disrupts microfilament organization. It is 10 to 100-fold more potent than cytochalasins.

SMILES string

S1C[C@H](NC1=O)[C@@]2(O[C@H]3C[C@@H](OC(=O)\C=C(/CC\C=C/[C@H](CC3)C)\C)C2)O

InChI

1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1

InChI key

NSHPHXHGRHSMIK-JRIKCGFMSA-N

description

Merck USA index - 14, 5378

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white to yellow

solubility

DMSO: 25 mg/mL
ethanol: 25 mg/mL
methanol: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

相关类别

Biochem/physiol Actions

主靶
肌动蛋白聚合
产物不与ATP竞争。
可逆：否
细胞渗透性：否

Disclaimer

毒性：有害（C）

General description

一种结构独特的海洋毒素。在体外抑制肌动蛋白的聚合并破坏微丝组织以及微丝介导的过程。效力比细胞松弛素高 10 至 100 倍。

Other Notes

Spector, I., et al. 1989.Cell Motil.Cytoskeleton13, 127.
de Oliveira, C.A., and Mantovani, B. 1988.Life Sci.43, 1825.
Coue, M., et al. 1987.FEBS Lett.213, 316.
Spector, I., et al. 1983.Science219, 493.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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