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LPD-12

Name: LPD-12
Brand: MM

A water soluble, amphiphilic α-helical lipopeptide detergent (LPD) that forms small micelles and effectively mimics lipid bilayers.

别名:

LPD-12, Lipopeptide Detergent-12, Ac-AO(C₁₂)AEAAEKAAKYAAEAAEKAAKAO(C₁₂)A-NH₂

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关于此项目

经验公式（希尔记法）:

C₁₃₁H₂₂₄N₃₂O₃₇

分子量:

2839.37

UNSPSC Code:

12352200

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属性

Quality Level

100

assay

≥95% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

CMC

<1 μM

solubility

water: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

说明

General description

A water soluble, amphiphilic α-helical lipopeptide detergent (LPD) that forms small micelles and effectively mimics lipid bilayers (solubility in PBS ~ 40 mM; micelle MW ~ 23,100; aggregation number ~ 8.1; partial specific volume ~ 0.77 cm³/g). Shown to not only solubilize but also stabilize bacteriorhodopsin, lactose permease and E. coli PagP protein ([LPD] ~ 250 µM and [protein] ~ 22 µM) by forming complexes and precluding aggregation. Useful for NMR and X-ray structural studies of membrane proteins.

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ac-Ala-Orn(dodecanoyl)-Ala-Glu-Ala-Ala-Glu-Lys-Ala-Ala-Lys-Tyr-Ala-Ala-Glu-Ala-Ala-Glu-Lys-Ala-Ala-Lys-Ala-Orn(dodecanoyl)-Ala-NH₂

McGregor, C.L., et al. 2003. Nat. Biotechnol.21, 171.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c