444237
MMP-8 Inhibitor I - CAS 236403-25-1 - Calbiochem
The MMP-8 Inhibitor I, also referenced under CAS 236403-25-1, controls the biological activity of MMP-8. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
MMP-8 Inhibitor I - CAS 236403-25-1 - Calbiochem, (3R)-(+)-[2-(4-Methoxybenzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-hydroxamate]
质量水平
方案
≥95% (HPLC)
表单
solid
效能
4 nM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
DMSO: 200 mg/mL
运输
ambient
储存温度
−20°C
一般描述
A cell-permeable, potent inhibitor of MMP-8 (neutrophil collagenase; IC50 = 4 nM).
A potent and cell-permeable inhibitor of MMP-8 (IC50 = 4 nM).
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
包装
Packaged under inert gas
其他说明
Prager, G.W., et al. 2004. Blood103, 955.
Matter, H., et al. 1999. J. Med. Chem.42, 1908.
Matter, H., et al. 1999. J. Med. Chem.42, 1908.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Chengxin Zhang et al.
Cells, 11(20) (2022-10-28)
Aortic dissection (AD) is a lethal aortic pathology without effective medical treatments since the underlying pathological mechanisms responsible for AD remain elusive. Matrix metalloproteinase-8 (MMP8) has been previously identified as a key player in atherosclerosis and arterial remodeling. However, the
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