MEK Inhibitor II - CAS 623163-52-0 - Calbiochem

A cell-permeable 1,4-naphthoquinone compound that acts as potent and selective inhibitor of MEK (IC₅₀ = 0.38 µM for MEK1). It shows little effect on PKC and PKA, and inhibits Raf1 and ERK1 only at much higher concentrations (IC₅₀ = 34.5 and 82.9 µM, respectively).

A cell-permeable, potent, and selective inhibitor of MEK (IC₅₀ = 380 nM for MEK1). Exhibits negligible inhibitory effects on protein kinase C (PKC) and protein kinase A (PKA). Inhibits Raf1 and ERK1 only at much higher concentrations (IC₅₀ = 34.5 µM and 82.9 µM, respectively).

Cell permeable: yes

Primary Target
MEK1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 0.38 µM for MEK1

Packaged under inert gas

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Bakare, O., et al. 2003. Bioorg. Med. Chem.11, 3165.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Carcinogenic / Teratogenic (D)