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主要文件

COA分析证书/COQ

444965

MEK Inhibitor VIII

Name: MEK Inhibitor VIII
Brand: MM

The MEK1/2 Inhibitor II, also referenced under CAS 212631-61-3, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

别名:

MEK Inhibitor VIII, N-Cyclopropylmethoxy-3,4,5-trifluoro-2-(4-iodo-2-methylphenylamino)benzamide

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About This Item

经验公式（希尔记法）:

C₁₈H₁₆F₃IN₂O₂

CAS Number:

212631-61-3

分子量:

476.23

UNSPSC代码:

12352200

质量水平

100

方案

≥98% (HPLC)

表单

solid

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze
protect from light

颜色

white

溶解性

DMSO: 45 mg/mL
ethanol: 45 mg/mL

运输

ambient

储存温度

2-8°C

InChI

1S/C18H16F3IN2O2/c1-9-6-11(22)4-5-14(9)23-17-12(7-13(19)15(20)16(17)21)18(25)24-26-8-10-2-3-10/h4-7,10,23H,2-3,8H2,1H3,(H,24,25)

InChI key

UHAXDAKQGVISBZ-UHFFFAOYSA-N

一般描述

A cell-permeable and orally available amino-benzamide compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2 (IC₅₀ = 8 nM) with an excellent selectivity over ERK, c-Src, Cdk′s, and PI 3-Kγ (IC₅₀ >1.0 µM). Reported to exhibit in vivo efficacy in several animal models of arthritis and hyperalgesia in rat and rabbit.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Pelletier, J.P., et al. 2003. Arthritis Rheum.48, 1582.
Ciruela, A., et al. 2003. Br. J. Pharmacol.138, 751.
Bhattachar, S.N., et al. 2002. Int. J. Pharm.236, 135.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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