444965
MEK Inhibitor VIII
The MEK1/2 Inhibitor II, also referenced under CAS 212631-61-3, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
MEK Inhibitor VIII, N-Cyclopropylmethoxy-3,4,5-trifluoro-2-(4-iodo-2-methylphenylamino)benzamide
InChI key
UHAXDAKQGVISBZ-UHFFFAOYSA-N
InChI
1S/C18H16F3IN2O2/c1-9-6-11(22)4-5-14(9)23-17-12(7-13(19)15(20)16(17)21)18(25)24-26-8-10-2-3-10/h4-7,10,23H,2-3,8H2,1H3,(H,24,25)
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 45 mg/mL, ethanol: 45 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable and orally available amino-benzamide compound that acts as a potent and non-ATP-competitive inhibitor of MEK1/2 (IC50 = 8 nM) with an excellent selectivity over ERK, c-Src, Cdk′s, and PI 3-Kγ (IC50 >1.0 µM). Reported to exhibit in vivo efficacy in several animal models of arthritis and hyperalgesia in rat and rabbit.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Pelletier, J.P., et al. 2003. Arthritis Rheum.48, 1582.
Ciruela, A., et al. 2003. Br. J. Pharmacol.138, 751.
Bhattachar, S.N., et al. 2002. Int. J. Pharm.236, 135.
Ciruela, A., et al. 2003. Br. J. Pharmacol.138, 751.
Bhattachar, S.N., et al. 2002. Int. J. Pharm.236, 135.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持