445820
Meriolin 2
Meriolin 2 primarily used in Inhibition.
别名:
Meriolin 2, 3-((2-Amino)pyrimidin-4-yl)-4-hydroxy-1H-pyrrolo[2,3-b]pyridine
assay
≥93% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 50 mg/mL
shipped in
ambient
Quality Level
General description
A cell-permeable, ATP-binding site-targeting azaindolopyrimidine compound that inhibits against Cdk2/A, Cdk9/T, DYRK1A, Cdk5/p25, CK1δ/ε, Cdk1/B, and GSK-3α/β kinase activity (IC50 = 18, 18, 35, 50, 50, 57, and 500 nM, respectively). Shown to induce DEVDase activity in SH-SY5Y neuroblastoma cultures (by 5.46-fold in 24 h at 1 µM) and exhibit antiproliferative activity toward SH-SY5Y, multiple myeloma KMS-11, human embryonic kidney HEK293, colorectal adenocarcinoma LS 174T, and glioma GBM cells in vitro (IC50 = 0.41, 0.6, 0.96, 1.06, and 1.21 µM, respectively).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Echalier, A., et al. 2008. J. Med. Chem.51, 737.
Bettayeb, K., et al. 2007. Cancer Res.67, 8325.
Bettayeb, K., et al. 2007. Cancer Res.67, 8325.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Regulatory Review (Z)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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