448105
c-Met Kinase Inhibitor III
The c-Met Kinase Inhibitor III controls the biological activity of c-Met.
别名:
c-Met Kinase Inhibitor III, 2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
DMSO: 50 mg/mL
运输
wet ice
储存温度
−20°C
一般描述
A 6-Benzyloxyquinoline derivative which acts as an ATP-competitive inhibitor against c-Met (IC50 = 9.3 nM), with more than 20 fold selectivity against a panel of 19 receptor tyrosine kinases and 8 serine/threonine kinases, in enzymatic assays. Also exhibits MKN45 cell growth inhibition (IC50 = 93 nM) and displays HDG-dependent anti-proliferative activity (IC50 = 300 nM) in HUVEC cultures, in vitro.
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Nishii, H., et al. 2009. Bioorg. Med. Chem. Lett.20, 1405.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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