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Merck
CN

454861

MNK1 Inhibitor

The MNK1 Inhibitor, also referenced under CAS 522629-08-9, controls the biological activity of MNK1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

别名:

MNK1 Inhibitor, 4-Amino-5-(4-fluoroanilino)-pyrazolo[3,4-d]pyrimidine, CGP 57380, MNK Inhibitor I, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor I

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关于此项目

经验公式（希尔记法）:
C11H9FN6
化学文摘社编号:
522629-08-9
分子量:
244.23
UNSPSC Code:
12352200
MDL number:
MFCD03861062

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产品名称

MNK1 Inhibitor, The MNK1 Inhibitor, also referenced under CAS 522629-08-9, controls the biological activity of MNK1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InChI

1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)

InChI key

UQPMANVRZYYQMD-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 15 mg/mL
ethanol: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Mitogen-activated protein kinase-interacting kinase 1 (MNK1)
Product competes with ATP.
Reversible: yes
Target IC50: 2.2 µM against mitogen-activated protein kinase-interacting kinase 1 (MNK1); 3 µM against eIF4E phosphorylation by MNK1 in 293 human embryonic kidney cells

Disclaimer

Toxicity: Toxic (F)

General description

A cell-permeable, reversible, and ATP-competitive pyrazolo-pyrimidine compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1; IC50 = 2.2 µM) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. Effectively inhibits eIF4E phosphorylation (IC50 = 3 µM) by MNK1 in 293 human embryonic kidney cells and serves as a useful tool in studying MNK1-mediated cellular signaling.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Topisirovic, I., et al. 2004. Cancer Res.64, 8639.
Worch, J., et al. 2004. Oncogene23, 9162.
Walsh, D., and Mohr, I. 2004. Genes Dev.18, 660.
Morley, S.J., and Naegele, S. 2002. J. Biol. Chem.277, 32855.
Knauf, U., et al. 2001. Mol. Cell. Biol.21, 5500.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

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Benedetta De Ponte Conti et al.
eLife, 10 (2021-11-18)
We performed a systematic analysis of the translation rate of tumor-infiltrating lymphocytes (TILs) and the microenvironment inputs affecting it, both in humans and in mice. Measurement of puromycin incorporation, a proxy of protein synthesis, revealed an increase of translating CD4+

相关内容

Human Kinome & InhibitorSelect™ Libraries

Human Kinome Poster: The InhibitorSelect™ Protein Kinase Inhibitor Libraries provide broad coverage of the human kinome as shown here. The depicted human kinome dendrogram of 518 kinases are classified into five broad groups, 90 families, and 145 subfamilies. Inhibitor coverage was assigned based upon published data related to potency (IC50, EC50, Kd, etc.) for individual kinases harvested from the literature. Colored dots denote which library contains an inhibitor with demonstrated potent activity against the designated kinase and do not necessarily reflect known specificity of the inhibitor. Coverage of lipid and atypical kinases are depicted as a separate dendrogram. As shown, Calbiochem® Protein Kinase Inhibitor Libraries cover all major kinase families including TK, CMGC, CAMK, AGC, CK1, STE, TKL, as well as Lipid or Atypical kinase families.

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