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474791

MG-132

Name: MG-132
Brand: MM

≥98% (HPLC), proteasome inhibitor, liquid

别名:

Z-Leu-Leu-Leu-al, InSolution MG-132, 碳苯并-L-亮氨酰-L-亮氨酰-L-亮氨酸，Z-LLL-CHO，蛋白酶体抑制剂XI, MG-132

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关于此项目

经验公式（希尔记法）:

C₂₆H₄₁N₃O₅

化学文摘社编号:

133407-82-6

分子量:

475.62

NACRES:

NA.77

UNSPSC Code:

12352200

MDL number:

MFCD00674886

Assay:

≥98% (HPLC)

Form:

liquid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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产品名称

MG-132, InSolution, ≥98%, 10 mM, reversible proteasome inhibitor

Quality Level

100

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

shipped in

wet ice

storage temp.

−20°C

SMILES string

[H]C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

InChI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChI key

TZYWCYJVHRLUCT-VABKMULXSA-N

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General description

高效、可逆和细胞可透过性蛋白酶体抑制剂（(K_i = 4 nM）。可通过26S复合物降低哺乳动物细胞和酵母可渗透菌株中泛素结合蛋白的降解，而不会影响其ATP酶或异肽酶的活性。可激活c-Jun N端激酶（JNK1）、抑制NF-κB的活化（IC₅₀ = 3 µM）。

Biochem/physiol Actions

产品不与ATP竞争。

可逆性：是

细胞渗透性：是

靶标IC₅₀：3 µM抑制NF-κB活化

靶标K_i：4 nM作为蛋白酶体抑制剂

Packaging

用惰性气体包装

Physical form

10 mM（1 mg/210 µl）或（5 mg/1050 l）MG-132 DMSO溶液（货号474790）提供。

Other Notes

Meriin, A.B., et al. 1998.J. Biol. Chem.273, 6373.
Adams, J., and Stein, R. 1996.Ann.Rep.Med. Chem.31, 279.
Lee, D.H., and Goldberg, A.L.1996.J. Biol. Chem.271, 27280.
Wiertz, E.J.H.J., et al. 1996.Cell84, 769.
Read, M.A., et al. 1995.Immunity2, 493.
Rock, K.L., et al. 1994.Cell78, 761.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性：刺激性（B）

存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

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Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae.

D H Lee et al.

The Journal of biological chemistry, 271(44), 27280-27284 (1996-11-01)

We have studied whether various agents that inhibit purified yeast and mammalian 26 S proteasome can suppress the breakdown of different classes of proteins in Saccharomyces cerevisiae. The degradation of short-lived proteins was inhibited reversibly by peptide aldehyde inhibitors of

p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway.

Clarissa Braun et al.

Cell stress, 5(12), 176-182 (2021-12-18)

Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory processes. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (mTORC1). However, additional pathways that

Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis.

A B Meriin et al.

The Journal of biological chemistry, 273(11), 6373-6379 (1998-04-16)

Inhibition of the major cytosolic protease, proteasome, has been reported to induce programmed cell death in several cell lines, while with other lines, similar inhibition blocked apoptosis triggered by a variety of harmful treatments. To elucidate the mechanism of pro-

The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol.

E J Wiertz et al.

Cell, 84(5), 769-779 (1996-03-08)

Human cytomegalovirus (HCMV) down-regulates expression of MHC class I products by selective proteolysis. A single HCMV gene, US11, which encodes an endoplasmic reticulum (ER) resident type-I transmembrane glycoprotein, is sufficient to cause this effect. In US11+cells, MHC class I molecules

Molecular Mechanism of HER2 Rapid Internalization and Redirected Trafficking Induced by Anti-HER2 Biparatopic Antibody.

Jackie Cheng et al.

Antibodies (Basel, Switzerland), 9(3) (2020-09-24)

Amplification and overexpression of HER2 (human epidermal growth factor receptor 2), an ErbB2 receptor tyrosine kinase, have been implicated in human cancer and metastasis. A bispecific tetravalent anti-HER2 antibody (anti-HER2-Bs), targeting two non-overlapping epitopes on HER2 in domain IV (trastuzumab)

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全球贸易项目编号

货号	GTIN
474791-5MG	04055977185522
474791-1MG	04055977185515

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