475820
丝裂霉素C，头状链霉菌，无载体
Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Induces apoptosis in gastric cancer cells.
别名:
丝裂霉素C，头状链霉菌，无载体
InChI
1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
InChI key
NWIBSHFKIJFRCO-WUDYKRTCSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
purple
solubility
water: <1 mg/mL, methanol: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
General description
抗生素和抗癌剂。通过在鸟嘌呤和腺嘌呤残基处交联DNA抑制DNA合成；破坏碱基对。诱导胃癌细胞凋亡。将细胞周期阻滞在G2期。功效：≥970 µg/mg。
Biochem/physiol Actions
功效： ≥ 970 μg/mg丝裂霉素C
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
Other Notes
Kryt, F.A., et al. 1996.Blood 89, 938.
Schwartz, G.K., et al. 1995.J. Natl.Cancer Inst.87, 1394.
Folnan, R.S., 1993.Oncology 50, 24.
Tomasz, M., et al. 1987.Science 235, 1204.
Schwartz, G.K., et al. 1995.J. Natl.Cancer Inst.87, 1394.
Folnan, R.S., 1993.Oncology 50, 24.
Tomasz, M., et al. 1987.Science 235, 1204.
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Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：高毒性 & 致癌性/致畸性（I）
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Carc. 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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