475840
米力农
A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 300 nM).
别名:
米力农, 1,6-二氢-2-甲基-6-氧-（3,4ʹ-联吡啶）-5-甲腈
InChI
1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
InChI key
PZRHRDRVRGEVNW-UHFFFAOYSA-N
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 20 mg/mL, ethanol: 3 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
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General description
cGMP抑制的磷酸二酯酶（PDE III；IC50 =300 nM）的细胞可渗透的选择性抑制剂。对心脏有正性变时性、离子移变性和血管舒张作用。
Biochem/physiol Actions
主要靶标
PDE 3
PDE 3
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
靶标IC50：PDE III为300 nM
Preparation Note
溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存2个月。
Other Notes
Bailey, J.M., et al. 1994.Anesthesiology 81, 616.
Wilhelm, D., et al. 1992.J. Cardiovasc.Pharmacol.20, 705.
Lindgren, S.H., et al. 1990.Acta.Phys.Scand.140, 209.
Harrison, S.A., et al. 1986.Mol.Pharmacol.29, 506.
Wilhelm, D., et al. 1992.J. Cardiovasc.Pharmacol.20, 705.
Lindgren, S.H., et al. 1990.Acta.Phys.Scand.140, 209.
Harrison, S.A., et al. 1986.Mol.Pharmacol.29, 506.
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Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：有毒（F）
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
J M Bailey et al.
Anesthesiology, 81(3), 616-622 (1994-09-01)
Milrinone is a phosphodiesterase inhibitor with positive inotropic and vasodilator effects that are useful in the treatment of ventricular dysfunction after cardiac surgery. However, the pharmacokinetics of the drug have been investigated only in healthy volunteers and in patients with
S H Lindgren et al.
Acta physiologica Scandinavica, 140(2), 209-219 (1990-10-01)
The inhibitors of the cGMP-inhibited, low-Km cAMP phosphodiesterase--milrinone and OPC 3911--and an inhibitor of a non-cGMP-inhibited low-Km cAMP phosphodiesterase--rolipram--were used to evaluate the functional importance of the two cAMP phosphodiesterase activities in vascular smooth muscle and in platelets. Vinpocetine, an
D Wilhelm et al.
Journal of cardiovascular pharmacology, 20(5), 705-714 (1992-01-01)
The cardiac in vitro effects of R 80122, a novel phosphodiesterase (PDE) inhibitor, were investigated and compared with those of the reference compound milrinone and of the calcium-sensitizer adibendan. In guinea pig left atria, both milrinone and R 80122 increased
S A Harrison et al.
Molecular pharmacology, 29(5), 506-514 (1986-05-01)
We have identified and highly purified a "low Km" cAMP phosphodiesterase from bovine cardiac muscle. This phosphodiesterase was inhibited by low concentrations of cGMP and has, therefore, been temporarily designated as cGMP-inhibited phosphodiesterase. After a 16,000-fold increase in specific activity
Luping Yu et al.
Development (Cambridge, England), 148(2) (2020-12-16)
Alternative splicing (AS) contributes to gene diversification, but the AS program during germline development remains largely undefined. Here, we interrupted pre-mRNA splicing events controlled by epithelial splicing regulatory protein 1 (ESRP1) and found that it induced female infertility in mice.
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