475858-M
Met30 Antagonist, SMER3
The Met30 Antagonist, SMER3 controls the biological activity of Met30. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
Met30 Antagonist, SMER3, Small-Molecule Enhancer of Rapamycin-3, 9H-Indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one, Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one, SCF Met30 Inhibitor
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关于此项目
经验公式（希尔记法）:
C11H4N4O2
分子量:
224.18
UNSPSC代码:
12352200
推荐产品
方案
≥97% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow
溶解性
DMSO: 10 mg/mL
储存温度
2-8°C
1 of 1
此商品 | MCGB40S01 | MCGB20S02 | MCGB10S02 |
|---|---|---|---|
| pore size 0.22 μm | pore size 0.22 μm | pore size 0.22 μm | pore size 0.22 μm |
| technique(s) gas filtration: suitable | technique(s) gas filtration: suitable | technique(s) gas filtration: suitable | technique(s) gas filtration: suitable |
| filtration area 2000 cm2 | filtration area 2000 cm2 | filtration area 1000 cm2 | filtration area 500 cm2 |
| product line Millidisk® Barrier 40 | product line Millidisk® 40 | product line Millidisk® 20 | product line Millidisk® 10 |
| sterility non-sterile | sterility non-sterile | sterility non-sterile | sterility non-sterile |
| matrix Durapore® | matrix Durapore® | matrix Durapore® | matrix Durapore® |
一般描述
A cell-permeable indenofurazinopyrazinone compound that is shown to directly target the F-box protein Met30 subunit of the Skp1-cullin-F-box (SCF) E3 ubiquitin ligase complex, disrupting Met30-Skp1 interaction and selectively inhibiting SCFMet30, but not SCFCdc4, E3 ubiquitin ligase activity. SMER3 is reported to act in a synthetic lethal fashion with rapamycin (Cat. Nos. 553210, 553211, & 553212) in both human lung cancer A549 and in yeast cultures. SMER3 treatment (10 to 30 µM) results in cell cycle arrest and morphological phenotype resembling that seen with temperature-sensitive Met30, but not Skp1 or Cdc4, mutant under non-permissive temperature in yeast cultures.
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
It is recommended to prepare a stock solution for 3 month use each time and store the unreconstituted material in solid form, protected from moisture and preferably under inert gas, for best long-term stability during storage.
其他说明
Aghajan, M., et al. 2010. Nature Biotechnol.28, 738.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Regulatory Review (Z)
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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