475895
莫能菌素，钠盐，高纯度
Polyether antibiotic that functions as a Na+ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane.
别名:
莫能菌素，钠盐，高纯度
InChI
1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35+,36-;/m0./s1
InChI key
XOIQMTLWECTKJL-FBZUZRIGSA-M
assay
≥97% (by Assay)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white to beige
solubility
chloroform: soluble, ethanol: soluble, methanol: soluble
shipped in
ambient
Quality Level
General description
聚醚抗生素，通过与能够穿过质膜的单价阳离子形成稳定的复合物，作为Na+离子载体发挥作用。阻断糖蛋白分泌。抑制HDL减少细胞胆固醇酯化的能力。还报告诱导肾上腺嗜铬细胞分泌儿茶酚胺。
Biochem/physiol Actions
主要靶标
起Na+离子载体的作用
起Na+离子载体的作用
产物不与ATP竞争。
可逆：否
细胞渗透性：否
Preparation Note
在复溶后存放于冰箱（4°C）。贮备液在4°C下可稳定保存至多6个月。在酸性溶液中不稳定。
Other Notes
Inabayashi, M., et al. 1995.Biochemistry34, 3455.
Mendez, A.J.1995.J. Biol. Chem.270, 5891.
Sakuragawa, N., et al. 1994.Biochim.Biophys.Acta1213, 193.
Griffin, T., et al. 1993.J. Natl.Cancer Inst.85, 292.
Rushfeldt, C., and Smedsrtod, B. 1993.Cancer Res.53, 658.
Hoya, A., and Venosa, R.A.1992.Biochem.Biophys.Acta1104, 123.
Kok, J.W.1992.J. Cell.Sci.103, 1139.
Takemura, H., and Ohshika, H. 1992.Biochem.Pharmacol.44, 1395.
Mendez, A.J.1995.J. Biol. Chem.270, 5891.
Sakuragawa, N., et al. 1994.Biochim.Biophys.Acta1213, 193.
Griffin, T., et al. 1993.J. Natl.Cancer Inst.85, 292.
Rushfeldt, C., and Smedsrtod, B. 1993.Cancer Res.53, 658.
Hoya, A., and Venosa, R.A.1992.Biochem.Biophys.Acta1104, 123.
Kok, J.W.1992.J. Cell.Sci.103, 1139.
Takemura, H., and Ohshika, H. 1992.Biochem.Pharmacol.44, 1395.
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Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：高毒性（H）
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - STOT RE 2
target_organs
Heart,muscle
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Bingqing Zheng et al.
International journal of molecular sciences, 22(14) (2021-07-25)
NK cells play crucial roles in defending against persistent HBV. However, NK cells present dysfunction in chronic hepatitis B virus (CHB) infection, and the associated mechanism is still not fully understood. Except for the regulatory receptors, NK cells could also
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