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NBI-31772 - CAS 374620-70-9 - Calbiochem

Name: NBI-31772 - CAS 374620-70-9 - Calbiochem
Brand: MM

别名:

NBI-31772 - CAS 374620-70-9 - Calbiochem, [1-(3ʹ,4ʹ-Dihydroxybenzoyl)-6,7-dihydroxyisoquinoline-3-carboxylic Acid]

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关于此项目

经验公式（希尔记法）:

C₁₇H₁₁NO₇

化学文摘社编号:

374620-70-9

分子量:

341.27

UNSPSC Code:

12352200

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属性

assay

≥95% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

green-yellow

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

−20°C

说明

General description

This product has been discontinued.

We are offering NBI 31772 hydrate (Cat. No. N8289) as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.

A non-peptide ligand that exhibits high-affinity (K_i ~ 1 - 17 nM) towards all six human insulin-like growth factor-I binding proteins (IGFBPs). Displaces insulin-like growth factor-I (IGF-I) from the IGF-I:IGFBP complex in 3T3 fibroblasts; however, it does not interact with the IGF receptors.

A non-peptide ligand derived from the transformation of L-3,4-dihydroxy-phenylalanine that exhibits high affinity binding to all six human insulin-like growth factor-I binding proteins (IGFGPs) (K_i = 3.36 nM for IGFBP-1, 1.18 nM for IGFBP-2, 5.64 nM for IGFBP-3, 1.54 nM for IGFBP-4, 3.90 nM for IGFBP-5, and 16.6 nM for IGFBP-6). Inhibits insulin-like growth factor (IGF-I) induced cell proliferation in 3T3 fibroblasts through the displacement of IGF-I from the IGF-I:GFBP complex. However, it does not interact with IGF receptors.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Human insulin-like growth factor-I binding proteins (IGFBPs).

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Chen, C., et al. 2001. J. Med. Chem.44, 4001.
Liu, X.J., et al. 2001. J. Biol. Chem.276, 32419.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c