480065
Necrostatin-1
≥95% (HPLC), crystalline solid, necroptosis inhibitor, Calbiochem
别名:
Necrostatin-1
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关于此项目
经验公式（希尔记法）:
C13H13N3OS
化学文摘社编号:
分子量:
259.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Necrostatin-1, Necrostatin-1, CAS 4311-88-0, is a cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α).
SMILES string
S=C1NC(C(=O)N1C)Cc2c3c([nH]c2)cccc3
InChI
1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
InChI key
TXUWMXQFNYDOEZ-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 10 mg/mL, methanol: 5 mg/mL
shipped in
ambient
Quality Level
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相关类别
General description
Biochem/physiol Actions
主要靶标
坏死性凋亡的阻滞剂
坏死性凋亡的阻滞剂
产物与ATP竞争。
可逆：否
在阻断用TNF-处理的FADD缺陷型Jurkat细胞的坏死中EC50=494 nMα
细胞可渗透性：具有
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
Other Notes
Degterev, A., et al. 2013.Nat. Chem. Biol.9, 192.
Degterev, A., et al. 2012.Cell Death Differ.20, 366.
Christofferson, D.E., et al. 2012.Cell Death Dis.3, e320.
Takahashi, N., et al. 2012.Cell Death Dis.3, e437.
Degterev, A., et al. 2008.Nat. Chem. Biol.4, 313.
Degterev, A., et al. 2005.Nat. Chem. Biol.1, 112.
Muller, A.J., et al. 2005.Nat. Med.11, 312.
Teng, X., et al. 2005.Bioorg.Med. Chem. Lett.15, 5039.
Degterev, A., et al. 2012.Cell Death Differ.20, 366.
Christofferson, D.E., et al. 2012.Cell Death Dis.3, e320.
Takahashi, N., et al. 2012.Cell Death Dis.3, e437.
Degterev, A., et al. 2008.Nat. Chem. Biol.4, 313.
Degterev, A., et al. 2005.Nat. Chem. Biol.1, 112.
Muller, A.J., et al. 2005.Nat. Med.11, 312.
Teng, X., et al. 2005.Bioorg.Med. Chem. Lett.15, 5039.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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