480458
NF-κB Activation Inhibitor X, Methysticin
别名:
NF-κB Activation Inhibitor X, Methysticin, (6R)-6-[(1E)-2-(1,3-Benzodioxol-5-yl)ethenyl]-5,6- dihydro-4-methoxy-2H-pyran-2-one
InChI
1S/C15H14O5/c1-17-12-7-11(20-15(16)8-12)4-2-10-3-5-13-14(6-10)19-9-18-13/h2-6,8,11H,7,9H2,1H3/b4-2+
InChI key
GTEXBOVBADJOQH-DUXPYHPUSA-N
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 50 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
Methysticin has been identified from kava to have potent NF-κB inhibitory activity and minimum toxicity. It is shown to inhibit NF-κB (IC50 = 0.19 µg/ml) 100 times more potently than traditional kava in A549 cells in an in vitro luciferase-based assay. It is also reported to suppress the elevation of IKKα, p65, and COX-2 and the degradation of IκBα in A549 cultures stimulated with TNF-alpha; through Western Blot analysis.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Shaik, A.A., et al. 2009. Bioorg Med Chem Lett.19, 5732.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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