481414
NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem
The NF-κB Activation Inhibitor VI, BOT-64, also referenced under CAS 113760-29-5, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
别名:
NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem, 6,6-Dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
ethanol: 10 mg/mL
DMSO: 50 mg/mL
运输
wet ice
储存温度
−20°C
一般描述
A cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser177 and/or Ser181 residues in the kinase′s activation loop domain. Shown to inhibit LPS-induced NF-κB activation and nitrite production (IC50 = 1.0 & 0.7 µM, respectively) in RAW 264.7 cells in vitro and effectively prevent LPS-induced septic death in mice (70% survival rate with 30 mg/kg BOT-64, i.p.) in vivo.
包装
Packaged under inert gas
其他说明
Kim, B.H., et al. 2008. Mol. Pharmacol.73, 1309.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Byung Hak Kim et al.
Molecular pharmacology, 73(4), 1309-1318 (2008-01-19)
Benzoxathiole derivatives have been used in the treatment of acne and have shown cytostatic, antipsoriatic, and antibacterial properties. However, little is known about the molecular basis for these pharmacological properties, although nuclear factor (NF)-kappaB activation is closely linked to inflammation
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