481414
NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem
The NF-κB Activation Inhibitor VI, BOT-64, also referenced under CAS 113760-29-5, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
别名:
NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem, 6,6-Dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
ethanol: 10 mg/mL, DMSO: 50 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
A cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser177 and/or Ser181 residues in the kinase′s activation loop domain. Shown to inhibit LPS-induced NF-κB activation and nitrite production (IC50 = 1.0 & 0.7 µM, respectively) in RAW 264.7 cells in vitro and effectively prevent LPS-induced septic death in mice (70% survival rate with 30 mg/kg BOT-64, i.p.) in vivo.
Packaging
Packaged under inert gas
Other Notes
Kim, B.H., et al. 2008. Mol. Pharmacol.73, 1309.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Byung Hak Kim et al.
Molecular pharmacology, 73(4), 1309-1318 (2008-01-19)
Benzoxathiole derivatives have been used in the treatment of acne and have shown cytostatic, antipsoriatic, and antibacterial properties. However, little is known about the molecular basis for these pharmacological properties, although nuclear factor (NF)-kappaB activation is closely linked to inflammation
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