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Merck
CN

481908

FK866 hydrochloride hydrate

The Nicotinamide Phosphoribosyltransferase Inhibitor, FK866, also referenced under CAS 658084-64-1, controls the biological activity of Nicotinamide Phosphoribosyltransferase. This small molecule/inhibitor is primarily used for Neuroscience applications.

别名:

烟酰胺磷酸核糖转移酶抑制剂，FK866, APO866，NAMPTase抑制剂I，PBEF抑制剂I，Visfatin抑制剂I，NAPRT抑制剂，（E）-N-（4-（1-苯甲酰基哌啶-4-基）丁基）-3-（吡啶-3-基）丙烯酰胺，NAMPT抑制剂

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关于此项目

经验公式（希尔记法）:
C24H29N3O2
化学文摘社编号:
658084-64-1
分子量:
391.51
MDL number:
MFCD10565943
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze
protect from light

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产品名称

烟酰胺磷酸核糖转移酶抑制剂，FK866, The Nicotinamide Phosphoribosyltransferase Inhibitor, FK866, also referenced under CAS 658084-64-1, controls the biological activity of Nicotinamide Phosphoribosyltransferase. This small molecule/inhibitor is primarily used for Neuroscience applications.

SMILES string

N2(CCC(CC2)CCCCNC(=O)\C=C\c3cnccc3)C(=O)c1ccccc1

InChI

1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+

InChI key

KPBNHDGDUADAGP-VAWYXSNFSA-N

assay

≥97% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

相关类别

Disclaimer

毒性：标准处理（A）

General description

一种可渗透细胞的吡啶基丙烯酰胺化合物，可作为选择性的变构NAPRT/NAMPT（烟酰胺磷酸核糖基转移酶）抑制剂（酶/底物复合物的Ki=0.4 nM；游离酶的Ki′=0.3 nM），同时对NPRT（烟酸磷酸核糖基转移酶）活性（K-562提取物中10 nM时NAPRT活性抑制82%，而1 µM时NPRT活性无抑制）没有影响。已显示FK866治疗可通过消耗HepG2和NIH-3T3培养物（在10 nM FK866治疗24小时后减少>95%）中的NAD+ （目录号481911 & 481915）来诱导细胞死亡，同样，已证明添加外源NAD+可从FK866诱导的NAD+消耗和细胞死亡中挽救NIH-3T3和SH-SY5Y。

Other Notes

Formentini, L., et al. 2009.Biochem.Pharmacol.77, 1612.
Nakahata, Y., et al. 2009.Science324, 654.
Ramsey.K.M., et al. 2009.Science324, 651.
Billington, R.A., et al. 2008.J. Biol. Chem.283, 6367.
Hasmann, M. and Schemainda, I., 2003.Cancer Res.63, 7436.

Packaging

用惰性气体包装

Physical form

以50 mM（2 mg/102.17 µl）DMSO溶液提供。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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