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487957

NOC-18

Name: NOC-18
Brand: MM

A nitric oxide (NO) donor similar to NOC-5, NOC-7 and NOC-12 but with an enhanced half-life.

别名:

NOC-18, DETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino) bis-ethanamine, DETA NONOate, DETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate

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关于此项目

经验公式（希尔记法）:

C₄H₁₃N₅O₂

化学文摘社编号:

146724-94-9

分子量:

163.18

UNSPSC Code:

12352200

Assay:

≥90% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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属性

Quality Level

100

assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white

solubility

PBS, pH 7.4: 100 mg/mL, 10 mM NaOH: soluble, water: soluble

shipped in

ambient

storage temp.

−20°C

InChI

1S/C4H13N5O2/c5-1-3-8(4-2-6)9(11)7-10/h11H,1-6H2/p+2

InChI key

HMRRJTFDJAVRMR-UHFFFAOYSA-P

说明

General description

A nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952) and NOC-12 (Cat. No. 487955) but with an enhanced half-life. Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu²⁺in vitro. Half-life (t_½) in PBS, pH 7.4 is 3400 minutes at 22°C. Relatively stable in alkaline solution (pH ≥10.0).

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution in NaOH, aliquot and freeze (-20°C). Stock solutions in NaOH are stable for up to 24 h at -20°C. Stock solutions in H₂O or PBS, pH 7.4 are unstable; reconstitute just prior to use.

Other Notes

Seccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306.
Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103.
Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519.
Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287.
Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

存储类别

10-13 - German Storage Class 10 to 13

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全球贸易项目编号

货号	GTIN
487957-10MG	04055977200430