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Merck
CN

5.00526

NOX抑制剂VII, Thr101

别名:

NOX抑制剂VII, Thr101

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关于此项目

经验公式(希尔记法):
C14H10FNOS
化学文摘社编号:
分子量:
259.30
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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InChI key

BUIZTXXZBDUOCR-UHFFFAOYSA-N

SMILES string

Fc1cc2c(cc1)C(=O)N(S2)c3c(cccc3)C

assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

light brown

solubility

DMSO: 50 mg/mL

Quality Level

General description

一种细胞可渗透的、硒被硫取代的依布硒啉衍生物,通过阻断p22phox c末端PRD(富含脯氨酸的结构域)和p47phoxbis-SH3相互作用表现出与依布硒啉相似的NOX2抑制活性。尽管在无细胞p22phox PRD-p47phoxbis-SH3结合(IC50 = 4 vs. 0.3 µM)和NOX2活性(IC50 = 4 vs. 0.6 µM)分析中Thr101的效力低于依布硒啉,但在基于细胞的测定中,Thr101的效力和NOX2选择性比依布硒啉更强(NOX2、NOX1、sNOX4和NOX5的Thr101 IC50 /依布硒啉IC50分别为0.3/0.5、3/0.15、8/无抑制作用、8/0.7 µM),并且没有谷胱甘肽过氧化物酶活性。请注意,由于变化的含水量,该化合物的分子量是批次特异性的。就特定批次的分子量,请参阅样品瓶标签或分析证书。所提供的分子量代表无水的基线分子量。

Biochem/physiol Actions

主要靶标
可阻止p22phox C末端PRD(富含脯氨酸的结构域)和p47phoxbis-SH3相互作用
细胞可渗透性:具有

Packaging

用惰性气体包装

Preparation Note

复溶后,等分并冷冻保存(-20°C)。贮备液在-20°C下可稳定保存至多3个月。

Other Notes

Smith, S.M.E., et al. 2012.Chem. Biol.19, 752.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

毒性:标准处理(A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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