5.04277
CB2 Inverse Agonist, SR 144528 - CAS 192703-06-3 - Calbiochem
别名:
CB2 Inverse Agonist, SR 144528 - CAS 192703-06-3 - Calbiochem, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3
InChI
1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)/t22-,27-,29+/m1/s1
InChI key
SUGVYNSRNKFXQM-XRHWURSXSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 20 mg/mL
storage temp.
−20°C
General description
A selective inverse agonist for peripheral cannabinoid (CB2) receptors (Ki = 0.6 nM and 400 nM for CB2 and CB1 receptors, respectively). Has been used in studies related to control of pain initiation, suppression of inflammation, and immune activation.
Biochem/physiol Actions
Primary Target
CB₂ Receptor
CB₂ Receptor
Target Ki: 0.6 nM and 400 nM for CB₂ and CB₁ receptors, respectively.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Barth, F., et al. 1999. Curr. Med. Chem.6, 745.
Iwamura, H., et al. 2001. J. Pharmacol. Exp. Ther.296, 420.
Wright, K., et al. 2008. Br. J. Pharmacol.153, 263.
Di Marzo, V. 2008. Nat. Rev. Drug Discov.7, 438.
Rinaldi-Carmona, M., et al. 1998. J. Pharmacol. Exp. Ther.284, 644.
Portier, M., et al. 1999. J. Pharmacol. Exp. Ther.288, 582.
Iwamura, H., et al. 2001. J. Pharmacol. Exp. Ther.296, 420.
Wright, K., et al. 2008. Br. J. Pharmacol.153, 263.
Di Marzo, V. 2008. Nat. Rev. Drug Discov.7, 438.
Rinaldi-Carmona, M., et al. 1998. J. Pharmacol. Exp. Ther.284, 644.
Portier, M., et al. 1999. J. Pharmacol. Exp. Ther.288, 582.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
法规信息
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