方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 20 mg/mL
储存温度
−20°C
InChI
1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)/t22-,27-,29+/m1/s1
InChI key
SUGVYNSRNKFXQM-XRHWURSXSA-N
一般描述
A selective inverse agonist for peripheral cannabinoid (CB2) receptors (Ki = 0.6 nM and 400 nM for CB2 and CB1 receptors, respectively). Has been used in studies related to control of pain initiation, suppression of inflammation, and immune activation.
生化/生理作用
Primary Target
CB₂ Receptor
CB₂ Receptor
Target Ki: 0.6 nM and 400 nM for CB₂ and CB₁ receptors, respectively.
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Barth, F., et al. 1999. Curr. Med. Chem.6, 745.
Iwamura, H., et al. 2001. J. Pharmacol. Exp. Ther.296, 420.
Wright, K., et al. 2008. Br. J. Pharmacol.153, 263.
Di Marzo, V. 2008. Nat. Rev. Drug Discov.7, 438.
Rinaldi-Carmona, M., et al. 1998. J. Pharmacol. Exp. Ther.284, 644.
Portier, M., et al. 1999. J. Pharmacol. Exp. Ther.288, 582.
Iwamura, H., et al. 2001. J. Pharmacol. Exp. Ther.296, 420.
Wright, K., et al. 2008. Br. J. Pharmacol.153, 263.
Di Marzo, V. 2008. Nat. Rev. Drug Discov.7, 438.
Rinaldi-Carmona, M., et al. 1998. J. Pharmacol. Exp. Ther.284, 644.
Portier, M., et al. 1999. J. Pharmacol. Exp. Ther.288, 582.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
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