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Merck
CN

5.04317

Sigma-Aldrich

5-Azacytidine - CAS 320-67-2 - Calbiochem

别名:

5-Azacytidine - CAS 320-67-2 - Calbiochem, 5′AzaC, 5-Azacitidine, Zcyd, 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one

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关于此项目

经验公式（希尔记法）:
C8H12N4O5
化学文摘社编号:
320-67-2
分子量:
244.20
MDL编号:
MFCD00006539
UNSPSC代码:
12352200

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方案

≥93% (HPLC)

质量水平

100

表单

powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)
protect from light

颜色

off-white

溶解性

water: 10 mg/mL
DMSO: 100 mg/mL

储存温度

2-8°C

InChI

1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1

InChI key

NMUSYJAQQFHJEW-KVTDHHQDSA-N

一般描述

This product has been discontinued.



A cell-permeable ribonucleoside analog of cytidine that is reported to readily incorporate into RNA and DNA, and inhibit protein synthesis. Causes DNA methyltransferases depletion, DNA hypomethylation and DNA damage. Selectively activates eukaryotic gene expression, and potently arrests the growth of several AML cells (EC50<4.0 µM). Enhances reprogramming efficiency (EC50 ~ 2.4 µM in iOSKM-MEFs). 5-Aza-2′-Deoxycytidine (ZaCyd) is also available (Cat. No. 189825) & (Cat. No. 189826).

A cell-permeable ribonucleoside analog of cytidine that is reported to readily incorporate into RNA and DNA, and inhibit protein synthesis. Causes DNA methyltransferases depletion, DNA hypomethylation and DNA damage. Selectively activates eukaryotic gene expression, and potently arrests the growth of several AML cells (EC50<4.0 µM). Enhances reprogramming efficiency (EC50 ~ 2.4 µM in iOSKM-MEFs). 5-Aza-2′-Deoxycytidine (ZaCyd) is also available (Cat. No. 189825) & (Cat. No. 189826).

生化/生理作用

Cell permeable: yes
Primary Target
DNA & RNA
Reversible: no

包装

Packaged under inert gas

制备说明

Unstable in H₂O. Following reconstitution, store at 4°C for <12 hr.

其他说明

Hollenbach, P.W., et al. 2010. PLoS ONE5, e9001.
Mikkelsen, T.S., et al. 2008. Nature454, 49.
Huangfu, D., et al. 2008. Nat. Biotech.26, 795.
Christman, J.K., 2002. Oncogene 21, 5483.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

法规信息

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