跳转至内容
Merck
CN

5.04317

5-Azacytidine - CAS 320-67-2 - Calbiochem

别名:

5-Azacytidine - CAS 320-67-2 - Calbiochem, 5′AzaC, 5-Azacitidine, Zcyd, 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C8H12N4O5
化学文摘社编号:
320-67-2
分子量:
244.20
UNSPSC Code:
12352200
MDL number:
MFCD00006539

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

InChI

1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1

InChI key

NMUSYJAQQFHJEW-KVTDHHQDSA-N

assay

≥93% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

off-white

solubility

water: 10 mg/mL, DMSO: 100 mg/mL

Quality Level

100

General description

This product has been discontinued.



A cell-permeable ribonucleoside analog of cytidine that is reported to readily incorporate into RNA and DNA, and inhibit protein synthesis. Causes DNA methyltransferases depletion, DNA hypomethylation and DNA damage. Selectively activates eukaryotic gene expression, and potently arrests the growth of several AML cells (EC50<4.0 µM). Enhances reprogramming efficiency (EC50 ~ 2.4 µM in iOSKM-MEFs). 5-Aza-2′-Deoxycytidine (ZaCyd) is also available (Cat. No. 189825) & (Cat. No. 189826).

A cell-permeable ribonucleoside analog of cytidine that is reported to readily incorporate into RNA and DNA, and inhibit protein synthesis. Causes DNA methyltransferases depletion, DNA hypomethylation and DNA damage. Selectively activates eukaryotic gene expression, and potently arrests the growth of several AML cells (EC50<4.0 µM). Enhances reprogramming efficiency (EC50 ~ 2.4 µM in iOSKM-MEFs). 5-Aza-2′-Deoxycytidine (ZaCyd) is also available (Cat. No. 189825) & (Cat. No. 189826).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
DNA & RNA
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Unstable in H₂O. Following reconstitution, store at 4°C for <12 hr.

Other Notes

Hollenbach, P.W., et al. 2010. PLoS ONE5, e9001.
Mikkelsen, T.S., et al. 2008. Nature454, 49.
Huangfu, D., et al. 2008. Nat. Biotech.26, 795.
Christman, J.K., 2002. Oncogene 21, 5483.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

法规信息

新产品
此项目有

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持