5.04345
BX471
别名:
BX471, N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752
InChI key
XQYASZNUFDVMFH-CQSZACIVSA-N
InChI
1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1
assay
≥98% (HPLC)
form
powder
potency
1-5 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white to beige
solubility
DMSO: ≥25 mg/mL
Quality Level
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General description
An orally active, selective antagonist for chemokine receptor 1 (CCR-1) (Ki = 1-5 nM). Has been used in studies related to intracellular calcium mobilization and migration of leukocytes mediated through CCR-1.
Biochem/physiol Actions
Primary Target
CCR1
CCR1
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Shahlaei, M., et al. 2011. J. Chemical Information and Modeling.51, 2717.
Reuss, R., et al. 2010. Mult Scler.16, 366.
Gladue, R., et al. 2010. Curr Top Med Chem10, 1268.
Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol.68, 435.
Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry.5, 791.
Reuss, R., et al. 2010. Mult Scler.16, 366.
Gladue, R., et al. 2010. Curr Top Med Chem10, 1268.
Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol.68, 435.
Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry.5, 791.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_c
Not applicable
法规信息
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