5.04373
Vicriviroc Malate - CAS 541503-81-5 - Calbiochem
别名:
Vicriviroc Malate - CAS 541503-81-5 - Calbiochem, (4,6-dimethylpyrimidin-5-yl)(4-((S)-4-((R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)methanone malate, SCH-D, Vicriviroc, SCH-417690
assay
≥90% (HPLC)
form
powder
potency
0.91 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
beige
solubility
DMSO: soluble
storage temp.
−20°C
Quality Level
General description
A potent, noncompetitive allosteric antagonist for CCR5 (IC50 = 0.91 nM). An effective entry inhibitor of HIV-1. Inhibits the initial stages of the virus life cycle. Efects can be resisted by mutation in the gp120 V3 region of HIV-1 both in vitro and in vivo.
Biochem/physiol Actions
Primary Target
CCR5
CCR5
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Berro, R., et al. 2012. Virology427, 158.
Velasco-Velzquez, M, et al. 2012. Cancer Res.72, 3839.
Zembruski, N., et al. 2011. J. Antimicrob. Chemother.66, 802.
Velasco-Velzquez, M, et al. 2012. Cancer Res.72, 3839.
Zembruski, N., et al. 2011. J. Antimicrob. Chemother.66, 802.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
法规信息
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