5.04373
Vicriviroc Malate - CAS 541503-81-5 - Calbiochem
别名:
Vicriviroc Malate - CAS 541503-81-5 - Calbiochem, (4,6-dimethylpyrimidin-5-yl)(4-((S)-4-((R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)methanone malate, SCH-D, Vicriviroc, SCH-417690
方案
≥90% (HPLC)
质量水平
表单
powder
效能
0.91 nM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
beige
溶解性
DMSO: soluble
储存温度
−20°C
一般描述
A potent, noncompetitive allosteric antagonist for CCR5 (IC50 = 0.91 nM). An effective entry inhibitor of HIV-1. Inhibits the initial stages of the virus life cycle. Efects can be resisted by mutation in the gp120 V3 region of HIV-1 both in vitro and in vivo.
生化/生理作用
Primary Target
CCR5
CCR5
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Berro, R., et al. 2012. Virology427, 158.
Velasco-Velzquez, M, et al. 2012. Cancer Res.72, 3839.
Zembruski, N., et al. 2011. J. Antimicrob. Chemother.66, 802.
Velasco-Velzquez, M, et al. 2012. Cancer Res.72, 3839.
Zembruski, N., et al. 2011. J. Antimicrob. Chemother.66, 802.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
法规信息
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