5.04596
TCN-201
别名:
TCN-201, 3-Chloro-4-fluoro-N-[(4-{[2-(phenylcarbonyl)hydrazino]carbonyl}phenyl)methyl]benzenesulfonamide, NMDA Antagonist X
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关于此项目
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
Storage condition:
OK to freeze, protect from light
assay
≥98% (HPLC)
Quality Level
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 5 mg/mL
storage temp.
2-8°C
InChI
1S/C21H17ClFN3O4S/c22-18-12-17(10-11-19(18)23)31(29,30)24-13-14-6-8-16(9-7-14)21(28)26-25-20(27)15-4-2-1-3-5-15/h1-12,24H,13H2,(H,25,27)(H,26,28)
InChI key
FYIBXBFDXNPBSF-UHFFFAOYSA-N
General description
A negative allosteric modulator selective for NR2A containing NMDA receptors (pIC50 = 6.8 and <4.3 µM for NR2A and NR2B, respectively). No effect on NR2B-containing NMDA receptors with concentrations less than 50 mM. Inhibition on NR2A containing NMDA receptors is glycine (or D-serine)-binding, but not glutamate-binding, dependent.
Biochem/physiol Actions
Primary Target
NMDA receptors
NMDA receptors
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Bettini. E., et al. 2010. J. Pharm. Exp. Ther.335, 644.
Shin, A., et al. 2011. Br. J. Pharmacol.166, 1002.
Edman, S., et al. 2012. Neuropharmacology63, 441.
Hansen, K., et al. 2012. J. Neurosci.32, 6197.
Shin, A., et al. 2011. Br. J. Pharmacol.166, 1002.
Edman, S., et al. 2012. Neuropharmacology63, 441.
Hansen, K., et al. 2012. J. Neurosci.32, 6197.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
signalword
Warning
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
target_organs
Central nervous system, Respiratory system
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
法规信息
新产品
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 5045960001 | 04055977243918 |