方案
≥99% (HPLC)
质量水平
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 10 mM
H2O: 10 mM
储存温度
2-8°C
InChI
1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)/p-1/t10-/m0/s1
InChI key
DNCAZYRLRMTVSF-JTQLQIEISA-M
一般描述
A non-selective antagonist for group I/II mGlu receptors (minimal values of IC50 reported = 40 and 15 µM for mGlu1 and mGlu2, respectively). Often used as an agent to differentiate excitatory neurotransmissions mediated by glutamate from other neurotransmitters (i.e. dopamine, acetylcholine, and GABA in early brain development). A common component of cocktails for blocking glutamate transmission in brain slice preparation.
生化/生理作用
Primary Target
Grup I and II mGlu receptors
Grup I and II mGlu receptors
Target IC50: 40 and 15 →M for mGlu₁ and mGlu₂, respectively.
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Fano, S., et al. 2012. Eur. J. Neurosci.36, 3628.
Wang, W., et al. 2012. J. Physiol.590, 3743.
Cortes, C., et al. 2013. Synapse. DOI: 10.1002/syn.21646.Schoepp, D.D., et al. 1999.
Neuropharmacol.38, 1431.
Wang, W., et al. 2012. J. Physiol.590, 3743.
Cortes, C., et al. 2013. Synapse. DOI: 10.1002/syn.21646.Schoepp, D.D., et al. 1999.
Neuropharmacol.38, 1431.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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