5.04637
(S)-MCPG
别名:
(S)-MCPG, (S)-α-Methyl-4-carboxyphenylglycine, Group I/II mGlu Antagonist, (S)-MCPG
InChI
1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)/p-1/t10-/m0/s1
InChI key
DNCAZYRLRMTVSF-JTQLQIEISA-M
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 10 mM, H2O: 10 mM
Quality Level
General description
A non-selective antagonist for group I/II mGlu receptors (minimal values of IC50 reported = 40 and 15 µM for mGlu1 and mGlu2, respectively). Often used as an agent to differentiate excitatory neurotransmissions mediated by glutamate from other neurotransmitters (i.e. dopamine, acetylcholine, and GABA in early brain development). A common component of cocktails for blocking glutamate transmission in brain slice preparation.
Biochem/physiol Actions
Primary Target
Grup I and II mGlu receptors
Grup I and II mGlu receptors
Target IC50: 40 and 15 →M for mGlu₁ and mGlu₂, respectively.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Fano, S., et al. 2012. Eur. J. Neurosci.36, 3628.
Wang, W., et al. 2012. J. Physiol.590, 3743.
Cortes, C., et al. 2013. Synapse. DOI: 10.1002/syn.21646.Schoepp, D.D., et al. 1999.
Neuropharmacol.38, 1431.
Wang, W., et al. 2012. J. Physiol.590, 3743.
Cortes, C., et al. 2013. Synapse. DOI: 10.1002/syn.21646.Schoepp, D.D., et al. 1999.
Neuropharmacol.38, 1431.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持