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5.04658

LY 367385 Hydrochloride

Name: LY 367385 Hydrochloride
Brand: MM

别名:

LY 367385 Hydrochloride, (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid

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关于此项目

经验公式（希尔记法）:

C₁₀H₁₁NO₄ · xHCl

化学文摘社编号:

198419-91-9

分子量:

209.20 (free base basis)

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

OK to freeze, protect from light

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assay

≥98% (HPLC)

Quality Level

100

form

powder

potency

8.8 μM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

H₂O: 18 mg/mL

storage temp.

2-8°C

InChI

1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1

InChI key

SGIKDIUCJAUSRD-QMMMGPOBSA-N

General description

A potent antagonist selective for mGlu_1a receptors (IC₅₀ = 8.8 µM and >100 µM for mGlu_1a and mGlu_5a, respectively). Negligible effect on group II and III mGlu receptors. Frequently used in studies assessing the functional roles of mGlu_1a in various brain functions and disorders in which neural transmissions via mGlu_1a receptors are involved.

Biochem/physiol Actions

Primary Target
mGlu₁ receptors

Physical form

Supplied as a hydrochloride salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Young, R., et al. 2013. J. Neurosci.33, 2526.
Chapman, A., et al. 1999. Eur. J. Pharmacol.368, 17.
Bruno, V., et al. 1999. Neuropharmacol.38, 199.

Clark, X., et al. 1997. Bioorg. Med. Chem. Lett.7, 2777.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c