5.04685
LY 354740
别名:
LY 354740, (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxy lic acid, Eglumegad, Eglumetad
InChI key
VTAARTQTOOYTES-RGDLXGNYSA-N
InChI
1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
1 M NaOH: 100 mM
Quality Level
General description
A highly potent agonist selective for group II (mGluR2/3) receptors (EC50 = 5.1 and 24.3 nM at mGlu2 and mGlu3 receptors respectively), No effect at other mGlu subtype receptors (mGlu1a, mGlu5a, mGlu4 or mGlu7) at concentration less than 100 µM. Biologically viable admitted orally or systematically. Widely used in studies of addiction, epilepsy, schizophrenia, hyperactivity, and sleep.
Biochem/physiol Actions
Primary Target
mGlu2/3 receptors
mGlu2/3 receptors
Packaging
Yes
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Siok, J., et al. 2012. Neuropharmacol.62, 226.
Fell, J., et al. 2012. Neuropharmacol.62, 1473.
Pilc, A., 2003. IDrugs.6, 71.
Klodzinska. A., 1999. Neuropharmacol.38, 1831.
Monn, J., 1997. J. Med. Chem.40, 528.
Schoepp, D., 1997. Neuropharmacol.36, 1.
Bond, A., 1997. Neuroreport.8, 1463.
Fell, J., et al. 2012. Neuropharmacol.62, 1473.
Pilc, A., 2003. IDrugs.6, 71.
Klodzinska. A., 1999. Neuropharmacol.38, 1831.
Monn, J., 1997. J. Med. Chem.40, 528.
Schoepp, D., 1997. Neuropharmacol.36, 1.
Bond, A., 1997. Neuroreport.8, 1463.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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