5.04713
CPCCOEt
别名:
CPCCOEt, (E)-Ethyl 1,1a,7,7a-tetrahydro-7-(hydroxyimino)cyclopropa[b]chromene-1a-carboxylate, mGlu1 Antagonist, CPCCOEt
InChI
1S/C13H13NO4/c1-2-17-12(15)13-7-9(13)11(14-16)8-5-3-4-6-10(8)18-13/h3-6,9,16H,2,7H2,1H3/b14-11-
InChI key
FXCTZFMSAHZQTR-KAMYIIQDSA-N
assay
≥98% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mM
Quality Level
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General description
A potent, negative allosteric modulator selective for mGlu1 receptors (IC50 = 6.5 µM). No effect on other mGlu subtype receptors and ionotropic glutamate receptors at concentrations less than 100 µM. Acts by inhibiting an intramolecular interaction between the agonist-bound extracellular domain and the transmembrane domain. Widely used for studies related to peripheral pain and central pain pathways.
Biochem/physiol Actions
Primary Target
mGlu₁ receptors
mGlu₁ receptors
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Luongo L, et al. 2013. Neuropharmacol.66, 317.
Jin, Y., et al. 2012. Pain Res. Treat.2012, 915706.
Tappe-Theodor, A., 2011. Mol Pain.7, 38.
Litschig, S., et al. 1999. Mol. Pharmacol.55, 453.
Annoura, H., et al. 1996. Bioorg. Med. Chem. Lett.6, 763.
Jin, Y., et al. 2012. Pain Res. Treat.2012, 915706.
Tappe-Theodor, A., 2011. Mol Pain.7, 38.
Litschig, S., et al. 1999. Mol. Pharmacol.55, 453.
Annoura, H., et al. 1996. Bioorg. Med. Chem. Lett.6, 763.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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