5.04745
AMN082 Dihydrochloride
别名:
AMN082 Dihydrochloride, N,N′-Dibenzhydrylethane-1,2-diamine dihydrochloride
方案
≥98% (HPLC)
质量水平
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 100 mM
储存温度
−20°C
InChI
1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H
InChI key
YRQCDCNQANSUPB-UHFFFAOYSA-N
一般描述
A potent, selective and systemically active positive allosteric modulator for mGlu7 receptor (EC50 = 64-290 nM). One of the most frequently used agent for assessing the functional roles of mGlu7 receptors in a variety of brain functions (i.e. sleep pattern, learning and memory, and locomotion) and disorders (i.e. depression, anxiety, and Parkinson′s disease). Induces internalization of mGlu7 receptors. Also acts on NMDA, AMPA, 5-HT receptors and norepinephrine transporter.
生化/生理作用
Primary Target
mGlu₇ receptors
mGlu₇ receptors
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Cavas, M., et al. 2013. Pharmacol. Biochem. Behav. 103, 756.
Sukoff, R., et al. 2011. J. Pharmacol. Exp. Ther. 338, 345.
Flor, X., et al. 2005. Neuropharmacology 49, 244.
Mitsukawa, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 12.
Greco, B., et al. 2010. J. Pharmacol. Exp. Ther. 332, 1064.
Pelkey, K., et al. 2007. Neuropharmacology. 52, 108.
Sukoff, R., et al. 2011. J. Pharmacol. Exp. Ther. 338, 345.
Flor, X., et al. 2005. Neuropharmacology 49, 244.
Mitsukawa, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 12.
Greco, B., et al. 2010. J. Pharmacol. Exp. Ther. 332, 1064.
Pelkey, K., et al. 2007. Neuropharmacology. 52, 108.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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