5.04745
AMN082 Dihydrochloride
别名:
AMN082 Dihydrochloride, N,N′-Dibenzhydrylethane-1,2-diamine dihydrochloride
InChI
1S/C28H28N2.2ClH/c1-5-13-23(14-6-1)27(24-15-7-2-8-16-24)29-21-22-30-28(25-17-9-3-10-18-25)26-19-11-4-12-20-26;;/h1-20,27-30H,21-22H2;2*1H
InChI key
YRQCDCNQANSUPB-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mM
storage temp.
−20°C
Quality Level
General description
A potent, selective and systemically active positive allosteric modulator for mGlu7 receptor (EC50 = 64-290 nM). One of the most frequently used agent for assessing the functional roles of mGlu7 receptors in a variety of brain functions (i.e. sleep pattern, learning and memory, and locomotion) and disorders (i.e. depression, anxiety, and Parkinson′s disease). Induces internalization of mGlu7 receptors. Also acts on NMDA, AMPA, 5-HT receptors and norepinephrine transporter.
Biochem/physiol Actions
Primary Target
mGlu₇ receptors
mGlu₇ receptors
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Cavas, M., et al. 2013. Pharmacol. Biochem. Behav. 103, 756.
Sukoff, R., et al. 2011. J. Pharmacol. Exp. Ther. 338, 345.
Flor, X., et al. 2005. Neuropharmacology 49, 244.
Mitsukawa, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 12.
Greco, B., et al. 2010. J. Pharmacol. Exp. Ther. 332, 1064.
Pelkey, K., et al. 2007. Neuropharmacology. 52, 108.
Sukoff, R., et al. 2011. J. Pharmacol. Exp. Ther. 338, 345.
Flor, X., et al. 2005. Neuropharmacology 49, 244.
Mitsukawa, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 12.
Greco, B., et al. 2010. J. Pharmacol. Exp. Ther. 332, 1064.
Pelkey, K., et al. 2007. Neuropharmacology. 52, 108.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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