5.04777
Yohimbine Hydrochloride
别名:
Yohimbine Hydrochloride, 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride, α2-Adrenoceptor Antagonist, Yohimbine Hydrochloride
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经验公式（希尔记法）:
C21H26N2O3 · xHCl
化学文摘社编号:
分子量:
354.44 (free base basis)
UNSPSC Code:
12352200
MDL number:
InChI
1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15-,17-,18-,19+;/m0./s1
InChI key
PIPZGJSEDRMUAW-VJDCAHTMSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
pale yellow
solubility
DMSO: 25 mM
storage temp.
−20°C
Quality Level
General description
A potent antagonist for α2-adrenoceptors (pKi values are 8.52, 8.00 and 9.17 for human α2a, α2B and α2C receptors respectively). Often used as pharmacological stressor in animal studies.
Yohimbine Hydrochloride is a potent antagonist for α₂-adrenoceptors, α2B and α2C receptors respectively).
Biochem/physiol Actions
Primary Target
→₂-adrenoceptor
→₂-adrenoceptor
Preparation Note
Following reconstitution, aliquot and freeze (-20°c). Stock solutions are stable for up to 3 months at -20°C.
Slight warming is required for complete solubilization.
Other Notes
Calu, D., et al. 2013. J. Neurosci.33, 214.
Doxey, L., et al. 1984. Naunyn Schmiedebergs Arch. Pharmacol.325, 136.
Goldberg, K., et al. 1987. Pharmacol. Rev.35, 143.
Lalchandani, et al. 2002. J. Pharmacol. Exp. Ther.303, 979.
Doxey, L., et al. 1984. Naunyn Schmiedebergs Arch. Pharmacol.325, 136.
Goldberg, K., et al. 1987. Pharmacol. Rev.35, 143.
Lalchandani, et al. 2002. J. Pharmacol. Exp. Ther.303, 979.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic (F)
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
存储类别
6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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