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5.04840

(R)-CPPene

Name: (R)-CPPene
Brand: MM

别名:

(R)-CPPene, (R)-4-[(2E)-3-Phosphono-2-propenyl]-2-piperazinecarboxylic acid, SDZ EAA 494, Midafotel

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关于此项目

经验公式（希尔记法）:

C₈H₁₅N₂O₅P

化学文摘社编号:

117414-74-1

分子量:

250.19

UNSPSC Code:

12352200

NACRES:

NA.77

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属性

assay

≥99% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

H₂O: 100 mM

storage temp.

2-8°C

InChI

1S/C8H15N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h1,5,7,9H,2-4,6H2,(H,11,12)(H2,13,14,15)/b5-1+/t7-/m1/s1

InChI key

VZXMZMJSGLFKQI-ABVWVHJUSA-N

说明

General description

A highly potent competitive antagonist of NMDA receptors (ED₅₀ = 39 nM; pA2 = 6.8). Biologically active admitted systemically. Frequently used in assessing the functional roles of NMDA receptors mediated neurotransmissions in a variety of research areas, such as excitotoxic cell death, apoptosis, bipolar disorders, ischemia, traumatic brain injury, epilepsy, and neuropathic pain.

Biochem/physiol Actions

Primary Target
NMDA receptors

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Lowe, D., et al. 1990. Neurosci. Lett.113, 315.
Bullock, R., et al. 1990. Stroke.21, 32.
Bespalov, A., et al. 1998. Eur. J. Pharmacol.351, 299.

Lowe, D., et al. 1994. Neurochem. Inter.25, 583.
Duty, S. 2012. CNS Drugs26, 1017.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c