5.04840
(R)-CPPene
别名:
(R)-CPPene, (R)-4-[(2E)-3-Phosphono-2-propenyl]-2-piperazinecarboxylic acid, SDZ EAA 494, Midafotel
InChI
1S/C8H15N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h1,5,7,9H,2-4,6H2,(H,11,12)(H2,13,14,15)/b5-1+/t7-/m1/s1
InChI key
VZXMZMJSGLFKQI-ABVWVHJUSA-N
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
H2O: 100 mM
Quality Level
General description
A highly potent competitive antagonist of NMDA receptors (ED50 = 39 nM; pA2 = 6.8). Biologically active admitted systemically. Frequently used in assessing the functional roles of NMDA receptors mediated neurotransmissions in a variety of research areas, such as excitotoxic cell death, apoptosis, bipolar disorders, ischemia, traumatic brain injury, epilepsy, and neuropathic pain.
Biochem/physiol Actions
Primary Target
NMDA receptors
NMDA receptors
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Lowe, D., et al. 1990. Neurosci. Lett.113, 315.
Bullock, R., et al. 1990. Stroke.21, 32.
Bespalov, A., et al. 1998. Eur. J. Pharmacol.351, 299.
Lowe, D., et al. 1994. Neurochem. Inter.25, 583.
Duty, S. 2012. CNS Drugs26, 1017.
Bullock, R., et al. 1990. Stroke.21, 32.
Bespalov, A., et al. 1998. Eur. J. Pharmacol.351, 299.
Lowe, D., et al. 1994. Neurochem. Inter.25, 583.
Duty, S. 2012. CNS Drugs26, 1017.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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