5.04904
Ifenprodil Hemitartrate
别名:
Ifenprodil Hemitartrate, erythro-4-(2-(4-Benzylpiperidin-1-yl)-1-hydroxypropyl)phenol hemitartrate
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关于此项目
经验公式（希尔记法）:
C21H27NO2 · 0.5C4H6O6
化学文摘社编号:
分子量:
400.49
UNSPSC Code:
12352200
MDL number:
InChI
1S/2C21H27NO2.C4H6O6/c2*1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17;5-1(3(7)8)2(6)4(9)10/h2*2-10,16,18,21,23-24H,11-15H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1
InChI key
DMPRDSPPYMZQBT-CEAXSRTFSA-N
assay
≥99% (HPLC)
form
solid
potency
0.15 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mM
Quality Level
General description
A partial non-competitive antagonist highly selective for GluN1/N2B subtype NMDA receptors (IC50 = 0.15 µM, maximal inhibition ˜90%) over other subtypes (IC50 = 39, 29, 76 µM for GluN1/N2A, GluN1/N2C and GluN1/N2D subtype receptors, respectively). Frequently used in studies of various brain functions and disorders involving neural transmissions mediated by GluN1/N2B subtype NMDA receptors.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Primary Target
GluN1/N2B subtype NMDA receptors
GluN1/N2B subtype NMDA receptors
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Zhang, H., et al. 2013. Mol. Brain.6, 13.
Kishimoto, A., et al. 2013. J. Clin. Psychopharmacol.33, 143.
Bhat, J., et al. 2013. Mol. Pharmacol.83, 9.
Amico-Ruvio, S., et al. 2012. 82, 1074, 81.
Bhattacharya, P., et al. 2012. Med. Hypotheses.79, 516.
Kishimoto, A., et al. 2013. J. Clin. Psychopharmacol.33, 143.
Bhat, J., et al. 2013. Mol. Pharmacol.83, 9.
Amico-Ruvio, S., et al. 2012. 82, 1074, 81.
Bhattacharya, P., et al. 2012. Med. Hypotheses.79, 516.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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