5.04906
Cuspin-1
别名:
Cuspin-1, (5-Bromo-3-pyridinyl)(4-methylphenyl)methanone, Survival Motor Neuron protein Upregulator, Cuspin-1
方案
≥94% (HPLC)
质量水平
表单
powder
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
brown
溶解性
DMSO: 10 mg/mL
储存温度
2-8°C
一般描述
A cell-permeable pyridinylphenyl-methanone compound that is reported to effectively upregulate SMN (survival of motor neuron) protein level in 3 out of 4 SMA (spinal muscular atrophy) patient-derived fibroblast lines (by 71% to 93% increase in 48 h; 5 µg/mL), but not HT1080, 293T, A549, two human ESC-MN lines, MEF, mESC-MN, rat PC12, or rat ST14A cells. Shown to preferentially stimulate cellular Erk (Thr202/Tyr204) over Akt (Ser473) phosphorylation in SMA fibroblast line 9677 in a time-dependent manner (tmax = 24 h; 10 µg/mL), indicative of Ras-Raf-MEK signaling pathway activation.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
生化/生理作用
Cell permeable: yes
Primary Target
Ras
Ras
Reversible: yes
包装
Packaged under inert gas
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Letso, R.R., et al. 2013. ACS Chem. Biol.8, 914.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
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