Cuspin-1

A cell-permeable pyridinylphenyl-methanone compound that is reported to effectively upregulate SMN (survival of motor neuron) protein level in 3 out of 4 SMA (spinal muscular atrophy) patient-derived fibroblast lines (by 71% to 93% increase in 48 h; 5 µg/mL), but not HT1080, 293T, A549, two human ESC-MN lines, MEF, mESC-MN, rat PC12, or rat ST14A cells. Shown to preferentially stimulate cellular Erk (Thr202/Tyr204) over Akt (Ser473) phosphorylation in SMA fibroblast line 9677 in a time-dependent manner (t_max = 24 h; 10 µg/mL), indicative of Ras-Raf-MEK signaling pathway activation.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Cell permeable: yes

Primary Target
Ras

Reversible: yes

Packaged under inert gas

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Letso, R.R., et al. 2013. ACS Chem. Biol.8, 914.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)