5.04983
S18986
别名:
S18986, (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide, (S)-2,3,3a,4-tetrahydro-1H-benzo[e]pyrrolo[2,1-c][1,2,4]thiadiazine 5,5-dioxide, AMPA Receptor Positive Allosteric Modulator, S18986
方案
≥97% (HPLC)
质量水平
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 100 mM
储存温度
2-8°C
InChI
1S/C10H12N2O2S/c13-15(14)9-5-2-1-4-8(9)12-7-3-6-10(12)11-15/h1-2,4-5,10-11H,3,6-7H2/t10-/m1/s1
InChI key
MNTIJYGEITVWHU-SNVBAGLBSA-N
一般描述
A positive allosteric modulator selective for the AMPA receptors. A nootropic and neuroprotective agents frequently used in researches studying cognition, memory, and aging related cognitive declines. Induces production of BNDF and AMPA-mediated release of noradrenaline and acetylcholine. Biologically viable admitted systematically.
生化/生理作用
Primary Target
AMPA
AMPA
Reversible: yes
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Gupta, K., et al. 2009. Cell Death & Differentiation.16, 624.
Marighetto, A., et al. 2008. Beh. Pharmacol.19, 235.
Bloss, B., et al. 2008. Exp. Neurol.210, 109.
Lockhart, P., et al. 2007. Eur. J. Pharmacol.561, 23.
Munoz, C., et al. 2004. Neurobiol. Aging.25, S224.
Rosi, S., et al. 2004. Neurosci. Lett.361, 120.
Lebrun, C., et al. 2000. Eur. J. Pharmacol.401, 205.
Lockhart, B., et al. 2000. Eur. J. Pharmacol.401, 145.
Marighetto, A., et al. 2008. Beh. Pharmacol.19, 235.
Bloss, B., et al. 2008. Exp. Neurol.210, 109.
Lockhart, P., et al. 2007. Eur. J. Pharmacol.561, 23.
Munoz, C., et al. 2004. Neurobiol. Aging.25, S224.
Rosi, S., et al. 2004. Neurosci. Lett.361, 120.
Lebrun, C., et al. 2000. Eur. J. Pharmacol.401, 205.
Lockhart, B., et al. 2000. Eur. J. Pharmacol.401, 145.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持