5.04983
S18986
别名:
S18986, (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide, (S)-2,3,3a,4-tetrahydro-1H-benzo[e]pyrrolo[2,1-c][1,2,4]thiadiazine 5,5-dioxide, AMPA Receptor Positive Allosteric Modulator, S18986
InChI key
MNTIJYGEITVWHU-SNVBAGLBSA-N
InChI
1S/C10H12N2O2S/c13-15(14)9-5-2-1-4-8(9)12-7-3-6-10(12)11-15/h1-2,4-5,10-11H,3,6-7H2/t10-/m1/s1
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mM
Quality Level
General description
A positive allosteric modulator selective for the AMPA receptors. A nootropic and neuroprotective agents frequently used in researches studying cognition, memory, and aging related cognitive declines. Induces production of BNDF and AMPA-mediated release of noradrenaline and acetylcholine. Biologically viable admitted systematically.
Biochem/physiol Actions
Primary Target
AMPA
AMPA
Reversible: yes
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Gupta, K., et al. 2009. Cell Death & Differentiation.16, 624.
Marighetto, A., et al. 2008. Beh. Pharmacol.19, 235.
Bloss, B., et al. 2008. Exp. Neurol.210, 109.
Lockhart, P., et al. 2007. Eur. J. Pharmacol.561, 23.
Munoz, C., et al. 2004. Neurobiol. Aging.25, S224.
Rosi, S., et al. 2004. Neurosci. Lett.361, 120.
Lebrun, C., et al. 2000. Eur. J. Pharmacol.401, 205.
Lockhart, B., et al. 2000. Eur. J. Pharmacol.401, 145.
Marighetto, A., et al. 2008. Beh. Pharmacol.19, 235.
Bloss, B., et al. 2008. Exp. Neurol.210, 109.
Lockhart, P., et al. 2007. Eur. J. Pharmacol.561, 23.
Munoz, C., et al. 2004. Neurobiol. Aging.25, S224.
Rosi, S., et al. 2004. Neurosci. Lett.361, 120.
Lebrun, C., et al. 2000. Eur. J. Pharmacol.401, 205.
Lockhart, B., et al. 2000. Eur. J. Pharmacol.401, 145.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持