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5.05208

Methyllycaconitine Citrate - CAS 21019-30-7 - Calbiochem

Name: Methyllycaconitine Citrate - CAS 21019-30-7 - Calbiochem
Brand: MM

别名:

Methyllycaconitine Citrate - CAS 21019-30-7 - Calbiochem, AChR Receptor Antagonist, Methyllycaconitine Citrate, alpha7beta2 recptor Antagonist, Methyllycaconitine Citrate, Methyllycaconitine; α7-Nicotinic Receptor Antagonist, Methyllycaconitine Citrate, Neuronal Nicotinic Receptor Antagonist, Methyllycacon, AChR Receptor Antagonist, Methyllycaconitine Citrate, alpha7beta2 recptor Antagonist, Methyllycaconitine Citrate, Methyllycaconitine; α7-Nicotinic Receptor Antagonist, Methyllycaconitine Citrate, Neuronal Nicotinic Receptor Antagonist, Methyllycaconi

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关于此项目

经验公式（希尔记法）:

C₃₇H₅₀N₂O₁₀ · xC₆H₈O₇

化学文摘社编号:

21019-30-7

分子量:

682.80 (salt-free basis)

UNSPSC Code:

12352200

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属性

assay

≥97% (HPLC)

form

solid

potency

1.4 nM K_i

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

water: 100 mM

storage temp.

−20°C

InChI

1S/C37H50N2O10/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3/t19?,21-,22-,24+,25+,27-,28+,29-,30+,33?,34+,35-,36+,37-/m1/s1

InChI key

XLTANAWLDBYGFU-ACDIZPBGSA-N

说明

General description

A potent antagonist highly selective for AChRs with α7 subunit (K_i = 1.4 nM for α7 subunit and >40 nM for α4β2 and α6β2 receptors). Frequently used in assessing the functional roles of AChRs with α7 subunit in brain functions and disorders (i.e. inflammatory and chronic neuropathic pain and parkinsonian neurodegeneration).

Biochem/physiol Actions

Primary Target
a7 AchR

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Suzuki, S., et al. 2013. J. Neurosci. Res.91, 462.
Freitas, K., et al. 2013. Neuropharmacol.65, 156.
Sheeja, N., et al. 2012. Hippocampus.22, 335.
Xiong, Y., et al. 2010. Pharmacol. Biochem. & Beha.95, 192.

Whiteaker, P., et al. 1999. Eur. J. Neurosci.11, 96.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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