5.05308
CDDO-Me
别名:
CDDO-Me, Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate, Bardoxolone methyl, BARD, NSC 713200, Nrf Activator V
方案
≥98% (HPLC)
质量水平
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 50 mg/mL
储存温度
2-8°C
InChI
1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
InChI key
WPTTVJLTNAWYAO-KPOXMGGZSA-N
一般描述
A cell-permeable, bioavailable synthetic oleanane triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties. Shown to significantly reduce the expression of several inflammatory mediators, including IL-6, IL-10, IL-12, TNFα, Mip1α and others. Reverses high fat diet-induced type 2 diabetes in C57BL/6 mice (3 mg/kg) and improves glucose homeostasis and insulin sensitivity. Down-regulates lipogenic gene expression in hepatocytes. Exhibits anti-proliferative activity in osteosarcoma cells (IC50 = 800, 150, 330, and 170 nM in HOB-c, KHOS, KHOSR2, and U2OS cells, respectively). Enhances the effectiveness of chemotherapeutic agents by inducing intrinsic mitochondrial-dependent apoptotic pathway. Reported to interact with multi cellular targets, namely, Nrf2-Keap1, IKK, JAK-STAT, PPARγ, ErbB2, PTEN, mTOR and Arp3 and covalently modify active site Cys residue via Michael addition.
生化/生理作用
Cell permeable: yes
Reversible: no
制备说明
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Use only fresh DMSO for reconstitution.
其他说明
Liby, K.T. and Sporn, M.B., 2012. Pharmacol. Rev.64, 972.
Saha, P.K. et al. 2010. J. Biol. Chem.285, 40581.
Ryu, K., et al. 2010. BMC Cancer10, 187.
Liby, K.T., et al. 2007. Nat. Rev. Cancer7, 357.
Shishodia S., et al. 2006. Clin. Cancer Res.12, 1828.
Zou, W., et al. 2004. Cancer Res.64, 7570.
Kim, Y., et al. 2002. J. Biol. Chem.277, 22320.
Konopleva, M., et al. 2002. Blood99, 326.
Wang, Y., et al. 2000. Mol Endocrinol.14, 1550.
Saha, P.K. et al. 2010. J. Biol. Chem.285, 40581.
Ryu, K., et al. 2010. BMC Cancer10, 187.
Liby, K.T., et al. 2007. Nat. Rev. Cancer7, 357.
Shishodia S., et al. 2006. Clin. Cancer Res.12, 1828.
Zou, W., et al. 2004. Cancer Res.64, 7570.
Kim, Y., et al. 2002. J. Biol. Chem.277, 22320.
Konopleva, M., et al. 2002. Blood99, 326.
Wang, Y., et al. 2000. Mol Endocrinol.14, 1550.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Toxicity: Standard Handling (A)
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°C)
Not applicable
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