5.05313
Hexamethonium Bromide
别名:
Hexamethonium Bromide, Hexane-1,6-bis(trimethylammonium bromide), Nicotinic Acetylcholine Receptors (nAChRs) Antagonist, Hexamethonium Bromide
InChI
1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
InChI key
FAPSXSAPXXJTOU-UHFFFAOYSA-L
assay
≥98% (TLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
H2O: 100 mg/mL
storage temp.
10-30°C
Quality Level
Biochem/physiol Actions
Primary Target
nAChR
nAChR
Disclaimer
Toxicity: Standard Handling (A)
General description
A potent antagonist of nicotinic acetylcholine receptors (nAChRs) at pre-ganglionic sites in both the sympathetic and parasympathetic nervous systems. Often used for studying the roles of nicotinic receptors in regulating cardiovascular system.
Other Notes
Dasgupta, X., et al., 2010. Proc. Natl. Acad. Sci.103, 6332.
Karavaev, N., et al., 2008. Neurosci. Behav. Physiol.38, 297.
Nelson, E., 1999. J. Physiol.516, 657.
Christ, D. 1980. Br. J. Pharmacol.69, 249.
Karavaev, N., et al., 2008. Neurosci. Behav. Physiol.38, 297.
Nelson, E., 1999. J. Physiol.516, 657.
Christ, D. 1980. Br. J. Pharmacol.69, 249.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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