5.05316
PHA-543,613
别名:
PHA-543,613, N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, Alpha 7 Nicotinic Acetylcholine Receptor (α7 nAChR) Agonist, PHA-543613
InChI key
IPKZCLGGYKRDES-ZDUSSCGKSA-N
InChI
1S/C15H17N3O2/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19)/t13-/m0/s1
assay
≥98% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 20 mg/mL
Quality Level
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General description
A potent agonist highly selective for α7 nicotinic acetylcholine receptor (α7 nAChR). Bioavaible admitted orally. Widely used in studies of the functional roles of α7 nAChR in learning and memory, sensory gating, and cognitive functions as well as Schizophrenia and Alzheimer′s disease.
Biochem/physiol Actions
Primary Target
α7 nAChR
α7 nAChR
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Mazurov, A., et al., 2011. J. Med. Chem.54, 7943.
Wishka, G., et al., 2006. J. Med. Chem.49, 4425.
Faghih, R., et al., 2008. J. Med. Chem.51, 701.
Wishka, G., et al., 2006. J. Med. Chem.49, 4425.
Faghih, R., et al., 2008. J. Med. Chem.51, 701.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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