5.05626
(S)-Sulpiride
别名:
(S)-Sulpiride, (S)-(-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide, D2-like dopamine antagonist, (s)-Sulpiride, Sulpiride
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Assay:
≥99% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
InChI
1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
InChI key
BGRJTUBHPOOWDU-UHFFFAOYSA-N
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 100 mM
Quality Level
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General description
Dopamine D2 receptor antagonist with good aqueous solubility. S-sulpiride (200 nm) was used to confirm that dopamine currents were mediated through the D2 receptor in whole animal rat brain preps. IC50 of 0.01012 µM Antagonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as inhibition of quinopirole-induced mitogenisis.
Biochem/physiol Actions
Primary Target
D2-like dopamine receptors
D2-like dopamine receptors
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Eagle, D. M. et al. 2011. J. Neurosci.31, 7349.
Banala, A. K. et al. 2011. J. Med. Chem.54, 3581.
Seeman, P. and Van Tol, H. H. 1994. Trends Pharmacol. Sci.15, 264.
Banala, A. K. et al. 2011. J. Med. Chem.54, 3581.
Seeman, P. and Van Tol, H. H. 1994. Trends Pharmacol. Sci.15, 264.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
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